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TRADD
Gene Name
TNFRSF1A-associated via death domain
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Death-inducing Signaling Complex
Receptor Complex
Membrane Raft
Molecular Function
Signal Transducer Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Kinase Binding
Protein Complex Binding
Identical Protein Binding
Binding, Bridging
Death Domain Binding
Biological Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Heterooligomerization
Positive Regulation Of Hair Follicle Development
Extrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Regulation by c-FLIP
Dimerization of procaspase-8
Caspase-8 activation by cleavage
Programmed Cell Death
Drugs
Diseases
GWAS
Protein-protein Interactions
24 interactors:
BCL10
BIRC2
CNTRL
DAPK1
FADD
FAS
GFRA1
HIPK2
KRT14
KRT18
NGFR
PPP2R1A
RIPK1
STAT1
TNF
TNFRSF10A
TNFRSF10B
TNFRSF1A
TNFRSF21
TNFRSF25
TRAF1
TRAF2
TRAF3
TRPC4AP
Entrez ID
8717
HPRD ID
04610
Ensembl ID
Uniprot IDs
B3KQZ9
Q15628
PDB IDs
1F2H
1F3V
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Apoptotic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Cell Death
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Apoptotic Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Tumor Necrosis Factor
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endopeptidase Activity
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Peptidase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Endopeptidase Activity
Cellular Response To Cytokine Stimulus
Regulation Of Peptidase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Proteolysis
Response To Cytokine
Programmed Necrotic Cell Death
Necrotic Cell Death
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Organic Substance
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Proteolysis
Necroptotic Signaling Pathway
Zymogen Activation
Negative Regulation Of Apoptotic Process
Cellular Response To Organic Substance
Signal Transduction
Negative Regulation Of Programmed Cell Death
Response To Mechanical Stimulus
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Death
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Necroptotic Process
Signaling
Cellular Response To Mechanical Stimulus
Cell Communication
Response To Abiotic Stimulus
Tagcloud
?
adaptor
appear
characterization
convey
daxx
death
domains
effector
fadd
far
growing
homologies
insights
isolation
jun
mammalian
members
mort
necrosis
represents
rip
seem
share
signals
superfamily
tnfr
traf
traf1
transmit