TRADD and TNFRSF25

Number of citations of the paper that reports this interaction (PubMedID 8934525)
0

Data Source:
HPRD (in vivo, two hybrid)

		TRADD	TNFRSF25
Description		TNFRSF1A associated via death domain	TNF receptor superfamily member 25
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GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex Receptor Complex	Extracellular Region Cytosol Plasma Membrane Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity Death Domain Binding	Tumor Necrosis Factor Receptor Activity Signaling Receptor Activity
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Inflammatory Response Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis	TNFs bind their physiological receptors
Drugs
Diseases
GWAS
Interacting Genes		24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP	9 interacting genes: BAG4 DAP3 DYRK1A MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		8717	8718
HPRD ID		04610	04532
Ensembl ID		ENSG00000102871	ENSG00000215788
Uniprot IDs		Q15628	Q93038
PDB IDs		1F2H 1F3V 5XME 6AC0 7CSQ	5YGP 5YGS
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Death Receptor Activity Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Death-inducing Signaling Complex Tumor Necrosis Factor Binding Negative Regulation Of Apoptotic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Lymphocyte Apoptotic Process Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Thioesterase Binding CD40 Receptor Complex Neuron Apoptotic Process Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Signaling Receptor Activity Negative Regulation Of Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death	Tumor Necrosis Factor Receptor Superfamily Complex Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Tumor Necrosis Factor Negative Regulation Of MRNA Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Intracellular Signaling Cassette Regulation Of Apoptotic Process Receptor Complex Regulation Of Programmed Cell Death Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Histone H3T45 Kinase Activity Diuretic Hormone Activity Positive Regulation Of Protein Phosphorylation Response To Epidermal Growth Factor Fructose Import Across Plasma Membrane Positive Regulation Of Signal Transduction TORC2 Complex Disassembly Negative Regulation Of MRNA Modification Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Cytosine Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly
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