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NEFH and PKN1
Number of citations of the paper that reports this interaction (PubMedID
8621664
)
0
Data Source:
HPRD
(in vitro, in vivo)
NEFH
PKN1
Description
neurofilament heavy chain
protein kinase N1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Intermediate Filament
Neurofilament
Postsynaptic Density
Axon
Cell Projection
Neurofibrillary Tangle
Schaffer Collateral - CA1 Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Membrane
Midbody
Cytoplasmic Vesicle
Cleavage Furrow
Protein-containing Complex
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Microtubule Binding
Kinesin Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Dynein Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Nucleotide Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Histone H3T11 Kinase Activity
Histone Binding
Histone Deacetylase Binding
Nuclear Androgen Receptor Binding
Protein Serine Kinase Activity
Biological Process
Microtubule Cytoskeleton Organization
Axonogenesis
Cell Projection Assembly
Neurofilament Bundle Assembly
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Bundle Assembly
Peripheral Nervous System Neuron Axonogenesis
Neurofilament Cytoskeleton Organization
Axon Development
Postsynaptic Modulation Of Chemical Synaptic Transmission
Postsynaptic Intermediate Filament Cytoskeleton Organization
Regulation Of Organelle Transport Along Microtubule
Cellular Response To Leukemia Inhibitory Factor
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Hyperosmotic Response
Signal Transduction
Epithelial Cell Migration
Negative Regulation Of B Cell Proliferation
Intracellular Signal Transduction
Post-translational Protein Modification
Positive Regulation Of DNA-templated Transcription
Spleen Development
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Cell Motility
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RAC1 GTPase cycle
Drugs
Fostamatinib
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
6 interacting genes:
ERBB2
MAPK1
NEFL
NEFM
PKN1
STXBP1
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DNAAF19
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
RHOB
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
Entrez ID
4744
5585
HPRD ID
01204
03019
Ensembl ID
ENSG00000100285
ENSG00000123143
Uniprot IDs
P12036
Q16512
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
?
Neurofilament Bundle Assembly
Postsynaptic Intermediate Filament Cytoskeleton
ERBB2-ERBB3 Signaling Pathway
ERBB3 Signaling Pathway
Intermediate Filament Bundle Assembly
Neurofilament
Schwann Cell Development
Phospholipase Binding
ERBB2 Signaling Pathway
Regulation Of Leukocyte Proliferation
Intermediate Filament Cytoskeleton
Cell Death
Apoptotic Process
Programmed Cell Death
Response To Epidermal Growth Factor
Protein Phosphorylation
Phosphorylation
Glial Cell Development
Epidermal Growth Factor Receptor Signaling Pathway
Axon
Intermediate Filament Organization
Negative Regulation Of Lymphocyte Proliferation
ERBB Signaling Pathway
Protein Kinase Activity
Negative Regulation Of Mononuclear Cell Proliferation
Neuromuscular Junction
Myelination
Axon Ensheathment
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Modulation Of Chemical Synaptic Transmission
Hematopoietic Or Lymphoid Organ Development
Positive Regulation Of Vesicle Docking
Negative Regulation Of Leukocyte Proliferation
Structural Constituent Of Cytoskeleton
Glial Cell Differentiation
ERBB3:ERBB2 Complex
Response To Acrylamide
Intermediate Filament Polymerization Or Depolymerization
Neuron Apoptotic Process
Presynaptic Intermediate Filament Cytoskeleton
Cytosine Metabolic Process
Kinase Activity
RNA Polymerase I Core Binding
Regulation Of Immune System Process
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Postsynaptic Intermediate Filament Cytoskeleton Organization
Histone H3T11 Kinase Activity
Positive Regulation Of Synaptic Transmission
Interleukin-34-mediated Signaling Pathway
Cytoskeleton
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Intermediate Filament
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Organelle Organization
Keratin Filament
Morphogenesis Of An Epithelium
Structural Constituent Of Cytoskeleton
Cytosol
Identical Protein Binding
Structural Molecule Activity
Protein Binding
Tissue Morphogenesis
Microtubule Binding
Regulation Of Microtubule-based Process
Microtubule
Cytoplasm
Regulation Of Microtubule Cytoskeleton Organization
Centrosome
Epithelial Cell Differentiation
Developmental Process
Microtubule Cytoskeleton Organization
Epidermis Development
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Postsynaptic Intermediate Filament Cytoskeleton Organization
Neurofilament Bundle Assembly
Protein Localization To Cytoskeleton
Intermediate Filament Cytoskeleton
Cellular Component Assembly
Microtubule-based Process
Postsynaptic Intermediate Filament Cytoskeleton
Tumor Necrosis Factor Receptor Superfamily Complex
Cellular Developmental Process
Axon Development
Neurofibrillary Tangle
Regulation Of Synapse Maturation
Tumor Necrosis Factor Binding
Gamma-tubulin Binding
Intermediate Filament Bundle Assembly
Cell Projection Organization
Regulation Of Organelle Transport Along Microtubule
Response To Electrical Stimulus
Regulation Of Canonical NF-kappaB Signal Transduction
Neurofilament Cytoskeleton Organization
Thioesterase Binding
Focal Adhesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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