NEFH and PKN1

Number of citations of the paper that reports this interaction (PMID 8621664)
12

Data Source:
HPRD (in vitro, in vivo)

		NEFH	PKN1
Gene Name		neurofilament, heavy polypeptide	protein kinase N1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Neurofilament Axon Neurofibrillary Tangle	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Microtubule Binding Kinesin Binding Protein Kinase Binding Protein Binding, Bridging Dynein Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Axon Development Regulation Of Organelle Transport Along Microtubule	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MAPK1 NEFL NEFM PKN1 STXBP1	40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282
Entrez ID		4744	5585
HPRD ID		01204	03019
Ensembl ID		ENSG00000100285	ENSG00000123143
Uniprot IDs		P12036	Q16512
PDB IDs			1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Neurofilament Bundle Assembly Intermediate Filament Bundle Assembly Regulation Of Axon Diameter Regulation Of Cell Projection Size Neurofilament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Peptidyl-threonine Phosphorylation Axon Cargo Transport Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Axon Development Synaptic Transmission Neuron Projection Morphogenesis Regulation Of Cellular Component Organization Stress-activated MAPK Cascade Establishment Of Localization In Cell Response To Wounding Stress-activated Protein Kinase Signaling Cascade Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Activation Of MAPK Activity Neuron Projection Development MAPK Import Into Nucleus Nervous System Development Cell Projection Morphogenesis Regulation Of Axonogenesis Cell Part Morphogenesis Cellular Localization Cell-cell Signaling Negative Regulation Of Neuron Apoptotic Process Response To Toxic Substance Regulation Of Stress-activated MAPK Cascade Neuron Development Platelet Activation Negative Regulation Of Neuron Death Regulation Of Golgi Inheritance Positive Regulation Of MAP Kinase Activity Cell Morphogenesis MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Cytosine Metabolic Process Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization	Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular	accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Difference) ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular	accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Intersection) ?