NEFH and NEFM

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vitro)

		NEFH	NEFM
Name		neurofilament heavy chain	neurofilament medium chain
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Postsynaptic Density Axon Cell Projection Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Axon Cell Projection Intermediate Filament Cytoskeleton Neurofibrillary Tangle Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Intermediate Filament Cytoskeleton Organization Intermediate Filament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor	Neurofilament Bundle Assembly
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Fear of minor pain ( 28701861 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Interleukin-6 levels ( 22205395 ) Metabolite levels ( 23823483 )
Interacting Genes		6 interacting genes: ERBB2 MAPK1 NEFL NEFM PKN1 STXBP1	12 interacting genes: APOE DISC1 DRD2 DSCAM FOS ITSN1 MINK1 NEFH RB1 SMAD2 STXBP1 TNIK
Entrez ID		4744	4741
HPRD ID		01204	01205
Ensembl ID		ENSG00000100285	ENSG00000104722
Uniprot IDs		P12036	P07197 Q9UK51
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Neurofilament Bundle Assembly Postsynaptic Intermediate Filament Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Intermediate Filament Bundle Assembly Neurofilament Schwann Cell Development Phospholipase Binding ERBB2 Signaling Pathway Regulation Of Leukocyte Proliferation Intermediate Filament Cytoskeleton Cell Death Apoptotic Process Programmed Cell Death Response To Epidermal Growth Factor Protein Phosphorylation Phosphorylation Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Axon Intermediate Filament Organization Negative Regulation Of Lymphocyte Proliferation ERBB Signaling Pathway Protein Kinase Activity Negative Regulation Of Mononuclear Cell Proliferation Neuromuscular Junction Myelination Axon Ensheathment Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Modulation Of Chemical Synaptic Transmission Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Vesicle Docking Negative Regulation Of Leukocyte Proliferation Structural Constituent Of Cytoskeleton Glial Cell Differentiation ERBB3:ERBB2 Complex Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Neuron Apoptotic Process Presynaptic Intermediate Filament Cytoskeleton Cytosine Metabolic Process Kinase Activity RNA Polymerase I Core Binding Regulation Of Immune System Process Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Histone H3T11 Kinase Activity Positive Regulation Of Synaptic Transmission Interleukin-34-mediated Signaling Pathway	Cell Projection Organization Axon Intracellular Signal Transduction Intracellular Signaling Cassette Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Glutamatergic Synapse Cell Projection Morphogenesis Neuron Projection Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Cellular Component Organization Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Dendritic Spine Development Positive Regulation Of Cell Development Modulation Of Chemical Synaptic Transmission Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Growth Hormone Secretion Regulation Of Axon Extension Cell-cell Signaling Regulation Of Growth Signal Transduction Regulation Of Growth Hormone Secretion Regulation Of Synapse Organization Positive Regulation Of Multicellular Organismal Process Signaling Regulation Of Developmental Growth Regulation Of Cellular Component Organization Cell Communication Intracellular Protein Localization Identical Protein Binding Memory Protein-containing Complex Binding Positive Regulation Of Cell Projection Organization Cell Population Proliferation Regulation Of Neurogenesis Regulation Of Postsynapse Organization Regulation Of Cell Growth Negative Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of Cell Development