NEFH

Description		neurofilament heavy chain
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Postsynaptic Density Axon Cell Projection Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Intermediate Filament Cytoskeleton Organization Intermediate Filament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Interacting Genes		6 interacting genes: ERBB2 MAPK1 NEFL NEFM PKN1 STXBP1
Entrez ID		4744
HPRD ID		01204
Ensembl ID		ENSG00000100285
Uniprot IDs		P12036
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurofilament Bundle Assembly Postsynaptic Intermediate Filament Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Intermediate Filament Bundle Assembly Neurofilament Schwann Cell Development Phospholipase Binding ERBB2 Signaling Pathway Regulation Of Leukocyte Proliferation Intermediate Filament Cytoskeleton Cell Death Apoptotic Process Programmed Cell Death Response To Epidermal Growth Factor Protein Phosphorylation Phosphorylation Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Axon Intermediate Filament Organization Negative Regulation Of Lymphocyte Proliferation ERBB Signaling Pathway Protein Kinase Activity Negative Regulation Of Mononuclear Cell Proliferation Neuromuscular Junction Myelination Axon Ensheathment Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Modulation Of Chemical Synaptic Transmission Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Vesicle Docking Negative Regulation Of Leukocyte Proliferation Structural Constituent Of Cytoskeleton Glial Cell Differentiation ERBB3:ERBB2 Complex Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Neuron Apoptotic Process Presynaptic Intermediate Filament Cytoskeleton Cytosine Metabolic Process Kinase Activity RNA Polymerase I Core Binding Regulation Of Immune System Process Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Histone H3T11 Kinase Activity Positive Regulation Of Synaptic Transmission Interleukin-34-mediated Signaling Pathway
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