NEFH

Gene Name		neurofilament, heavy polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Neurofilament Axon Neurofibrillary Tangle
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Microtubule Binding Kinesin Binding Protein Kinase Binding Protein Binding, Bridging Dynein Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Axon Development Regulation Of Organelle Transport Along Microtubule
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: MAPK1 NEFL NEFM PKN1 STXBP1
Entrez ID		4744
HPRD ID		01204
Ensembl ID		ENSG00000100285
Uniprot IDs		P12036
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurofilament Bundle Assembly Intermediate Filament Bundle Assembly Regulation Of Axon Diameter Regulation Of Cell Projection Size Neurofilament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Peptidyl-threonine Phosphorylation Axon Cargo Transport Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Axon Development Synaptic Transmission Neuron Projection Morphogenesis Regulation Of Cellular Component Organization Stress-activated MAPK Cascade Establishment Of Localization In Cell Response To Wounding Stress-activated Protein Kinase Signaling Cascade Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Activation Of MAPK Activity Neuron Projection Development MAPK Import Into Nucleus Nervous System Development Cell Projection Morphogenesis Regulation Of Axonogenesis Cell Part Morphogenesis Cellular Localization Cell-cell Signaling Negative Regulation Of Neuron Apoptotic Process Response To Toxic Substance Regulation Of Stress-activated MAPK Cascade Neuron Development Platelet Activation Negative Regulation Of Neuron Death Regulation Of Golgi Inheritance Positive Regulation Of MAP Kinase Activity Cell Morphogenesis MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Cytosine Metabolic Process Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization
Tagcloud ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular