NEFH and NEFL

Number of citations of the paper that reports this interaction (PMID 9388258)
6

Data Source:
HPRD (in vitro)

		NEFH	NEFL
Gene Name		neurofilament, heavy polypeptide	neurofilament, light polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Neurofilament Axon Neurofibrillary Tangle	Cytoplasm Cytosol Neurofilament Axon Growth Cone TSC1-TSC2 Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Microtubule Binding Kinesin Binding Protein Kinase Binding Protein Binding, Bridging Dynein Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Axon Development Regulation Of Organelle Transport Along Microtubule	Microtubule Cytoskeleton Organization Synaptic Transmission Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axon Transport Of Mitochondrion Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MAPK1 NEFL NEFM PKN1 STXBP1	29 interactors: BRD7 CCNC CDK5RAP2 CHD3 ENKD1 GRIN1 KDM1A KIFC3 KRT15 MAP2 MTMR2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SPTAN1 TERF1 TEX11 TSC1 TXLNB USP2 VIM YWHAG
Entrez ID		4744	4747
HPRD ID		01204	01206
Ensembl ID		ENSG00000100285
Uniprot IDs		P12036	P07196
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurofilament Bundle Assembly Intermediate Filament Bundle Assembly Regulation Of Axon Diameter Regulation Of Cell Projection Size Neurofilament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Peptidyl-threonine Phosphorylation Axon Cargo Transport Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Axon Development Synaptic Transmission Neuron Projection Morphogenesis Regulation Of Cellular Component Organization Stress-activated MAPK Cascade Establishment Of Localization In Cell Response To Wounding Stress-activated Protein Kinase Signaling Cascade Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Activation Of MAPK Activity Neuron Projection Development MAPK Import Into Nucleus Nervous System Development Cell Projection Morphogenesis Regulation Of Axonogenesis Cell Part Morphogenesis Cellular Localization Cell-cell Signaling Negative Regulation Of Neuron Apoptotic Process Response To Toxic Substance Regulation Of Stress-activated MAPK Cascade Neuron Development Platelet Activation Negative Regulation Of Neuron Death Regulation Of Golgi Inheritance Positive Regulation Of MAP Kinase Activity Cell Morphogenesis MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Cytosine Metabolic Process Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization	Nervous System Development Developmental Process Anatomical Structure Development Regulation Of Cellular Component Organization System Development Central Nervous System Development Organelle Organization Cell Differentiation Cell Projection Organization Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Neurogenesis Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Cell Cycle Cell Development Movement Of Cell Or Subcellular Component Microtubule-based Process Intermediate Filament Organization Axonogenesis Regulation Of Cellular Process Response To Stimulus G2/M Transition Of Mitotic Cell Cycle Axon Development Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Cellular Component Maintenance Chromatin Modification Negative Regulation Of Biosynthetic Process Neuron Development Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Myelination Axon Ensheathment Chromosome Organization Cell Cycle Process Regulation Of Gene Expression Regulation Of Microtubule-based Process Chromatin Organization Cell Morphogenesis Involved In Differentiation Intermediate Filament Cytoskeleton Organization Neuron Differentiation Intermediate Filament-based Process Protein Oligomerization Microtubule Bundle Formation Microtubule Cytoskeleton Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Tagcloud ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?