NEFH and NEFL

Number of citations of the paper that reports this interaction (PubMedID 9388258)
0

Data Source:
HPRD (in vitro)

		NEFH	NEFL
Description		neurofilament heavy chain	neurofilament light chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Postsynaptic Density Axon Cell Projection Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Neurofilament Axon Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton	Structural Constituent Of Cytoskeleton Protein Binding Tubulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Intermediate Filament Cytoskeleton Organization Intermediate Filament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor	Microtubule Cytoskeleton Organization Axonogenesis Anterograde Axonal Transport Retrograde Axonal Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Intermediate Filament Bundle Assembly Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Regulation Of Synapse Maturation Motor Neuron Apoptotic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide Negative Regulation Of Motor Neuron Apoptotic Process
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Fear of minor pain ( 28701861) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		6 interacting genes: ERBB2 MAPK1 NEFL NEFM PKN1 STXBP1	55 interacting genes: BRD7 CCDC13 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES DSCAM ENKD1 FXR1 GFAP GOLGA2 GORASP1 GRIN1 HGS ITSN1 KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO15B MYO5A NDN NEFH NEIL3 NEK6 NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 RBM11 SHANK3 SKIL SMYD1 SPTAN1 TERF1 TEX11 TRIM55 TRIM63 TSC1 TXLNB USHBP1 USP2 VIM YWHAG
Entrez ID		4744	4747
HPRD ID		01204	01206
Ensembl ID		ENSG00000100285	ENSG00000277586
Uniprot IDs		P12036	P07196
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurofilament Bundle Assembly Postsynaptic Intermediate Filament Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Intermediate Filament Bundle Assembly Neurofilament Schwann Cell Development Phospholipase Binding ERBB2 Signaling Pathway Regulation Of Leukocyte Proliferation Intermediate Filament Cytoskeleton Cell Death Apoptotic Process Programmed Cell Death Response To Epidermal Growth Factor Protein Phosphorylation Phosphorylation Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Axon Intermediate Filament Organization Negative Regulation Of Lymphocyte Proliferation ERBB Signaling Pathway Protein Kinase Activity Negative Regulation Of Mononuclear Cell Proliferation Neuromuscular Junction Myelination Axon Ensheathment Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Modulation Of Chemical Synaptic Transmission Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Vesicle Docking Negative Regulation Of Leukocyte Proliferation Structural Constituent Of Cytoskeleton Glial Cell Differentiation ERBB3:ERBB2 Complex Response To Acrylamide Intermediate Filament Polymerization Or Depolymerization Neuron Apoptotic Process Presynaptic Intermediate Filament Cytoskeleton Cytosine Metabolic Process Kinase Activity RNA Polymerase I Core Binding Regulation Of Immune System Process Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Histone H3T11 Kinase Activity Positive Regulation Of Synaptic Transmission Interleukin-34-mediated Signaling Pathway	Cytoskeleton Microtubule Microtubule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Intermediate Filament Organization Organelle Organization Centrosome Structural Constituent Of Cytoskeleton Intermediate Filament Cell Projection Microtubule-based Process Regulation Of Nervous System Development Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Neuron Projection Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Neurogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Plasma Membrane Bounded Cell Projection Organization Scaffold Protein Binding Dendritic Spine Cell Projection Organization Microtubule Organizing Center Organization Gamma-tubulin Binding Protein Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Nervous System Development Regulation Of Cell Development Regulation Of Cell Projection Organization Microtubule Organizing Center Regulation Of Cell Differentiation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Kinesin Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein-containing Complex Assembly Organelle Assembly Calmodulin Binding
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