NEFH and STXBP1

Number of citations of the paper that reports this interaction (PMID 12963086)
9

Data Source:
HPRD (in vivo)

		NEFH	STXBP1
Gene Name		neurofilament, heavy polypeptide	syntaxin binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Neurofilament Axon Neurofibrillary Tangle	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Platelet Alpha Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Microtubule Binding Kinesin Binding Protein Kinase Binding Protein Binding, Bridging Dynein Binding	SNARE Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Axon Development Regulation Of Organelle Transport Along Microtubule	Platelet Degranulation Energy Reserve Metabolic Process Vesicle Docking Involved In Exocytosis Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Maturation Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Protein Stabilization Long Term Synaptic Depression Platelet Aggregation Protein Localization To Plasma Membrane
Pathways			Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MAPK1 NEFL NEFM PKN1 STXBP1	27 interactors: APBA1 APBA2 APP CDK5 CDK5R1 DOC2A DOC2B DYT10 HGS MAPT NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SQSTM1 STX11 STX19 STX1A STX1B STX2 STX3 SYTL4 TRIM38 USO1
Entrez ID		4744	6812
HPRD ID		01204	04235
Ensembl ID		ENSG00000100285	ENSG00000136854
Uniprot IDs		P12036	B7Z1V5 P61764 Q68CM6
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurofilament Bundle Assembly Intermediate Filament Bundle Assembly Regulation Of Axon Diameter Regulation Of Cell Projection Size Neurofilament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Peptidyl-threonine Phosphorylation Axon Cargo Transport Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Axon Development Synaptic Transmission Neuron Projection Morphogenesis Regulation Of Cellular Component Organization Stress-activated MAPK Cascade Establishment Of Localization In Cell Response To Wounding Stress-activated Protein Kinase Signaling Cascade Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Activation Of MAPK Activity Neuron Projection Development MAPK Import Into Nucleus Nervous System Development Cell Projection Morphogenesis Regulation Of Axonogenesis Cell Part Morphogenesis Cellular Localization Cell-cell Signaling Negative Regulation Of Neuron Apoptotic Process Response To Toxic Substance Regulation Of Stress-activated MAPK Cascade Neuron Development Platelet Activation Negative Regulation Of Neuron Death Regulation Of Golgi Inheritance Positive Regulation Of MAP Kinase Activity Cell Morphogenesis MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Cytosine Metabolic Process Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization	Synaptic Transmission Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Synaptic Vesicle Transport Cell-cell Signaling Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Secretion By Cell Neurotransmitter Transport Vesicle Fusion Establishment Of Vesicle Localization Vesicle Localization Secretion Establishment Of Organelle Localization Cellular Localization Exocytosis Organelle Fusion Vesicle Docking Intracellular Transport Membrane Docking Organelle Localization Membrane Fusion Protein Localization Regulation Of Exocytosis Regulation Of Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Protein Transport Signaling Transport Cell Communication Vesicle Organization Positive Regulation Of Exocytosis Vesicle-mediated Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Peptidyl-threonine Phosphorylation Regulation Of Secretion Axon Cargo Transport Regulation Of Signaling Organelle Organization Positive Regulation Of Secretion Histone H3-T6 Phosphorylation Neurofilament Bundle Assembly Positive Regulation Of Transport Serine Phosphorylation Of STAT3 Protein Nervous System Development Regulation Of Synaptic Vesicle Transport
Tagcloud ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Difference) ?		carriers certainty cryb2 d22s268 d22s280 deafness dominantly gadolinium gardner inherited linkage manifestations manifests mri neuro neurofibromatosis neurologic nf2 ophthalmologic otologic pedigree predisposes presymptomatic schwannomas slowly spine thoroughly typically vestibular	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Intersection) ?