TOPBP1 and UBR5

Number of citations of the paper that reports this interaction (PMID 11714696)
31

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, two hybrid, in vitro)

		TOPBP1	UBR5
Gene Name		topoisomerase (DNA) II binding protein 1	ubiquitin protein ligase E3 component n-recognin 5
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Chromosome Cytoplasm Golgi Apparatus Centrosome Actin Cytoskeleton PML Body	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding
	Biological Process	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Catenin Import Into Nucleus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Progesterone Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)
Protein-Protein Interactions		19 interactors: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CHEK1 CLSTN1 E2F1 PML POLE PPP1CC RAD9A TBC1D4 TCFL5 TICRR TOP2B UBR5 ZBTB17	23 interactors: BARD1 CIB1 DYRK2 GSK3B KPNA1 KPNA2 KPNB1 MAPK1 NR1I2 PAIP1 PAIP2 PGR SATB1 SMAD2 TCEA1 TOPBP1 TP53 UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3
Entrez ID		11073	51366
HPRD ID		09678	06436
Ensembl ID		ENSG00000163781	ENSG00000104517
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	E7EMW7 O95071
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO	1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Checkpoint Cellular Response To Stress Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint DNA Repair Regulation Of Response To DNA Damage Stimulus Response To Radiation DNA Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Induced Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction G2 DNA Damage Checkpoint Cellular Response To Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Cellular Response To Stress Protein Polyubiquitination DNA Repair Cellular Response To Stimulus Protein K11-linked Ubiquitination Response To Organic Substance Apoptotic Process Programmed Cell Death Cell Death Death Response To Stimulus Viral Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nucleocytoplasmic Transport Regulation Of Intracellular Transport Nuclear Transport Negative Regulation Of Gene Expression Protein Import Positive Regulation Of Metabolic Process Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Toll-like Receptor 3 Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Growth Factor NLS-bearing Protein Import Into Nucleus Toll-like Receptor 4 Signaling Pathway
Tagcloud ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv	aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities
Tagcloud (Difference) ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv	aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities
Tagcloud (Intersection) ?