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TOPBP1 and PML
Number of citations of the paper that reports this interaction (PubMedID
12773567
)
60
Data Source:
HPRD
(in vivo)
TOPBP1
PML
Description
DNA topoisomerase II binding protein 1
PML nuclear body scaffold
Image
GO Annotations
Cellular Component
Condensed Nuclear Chromosome
Spindle Pole
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Nuclear Body
PML Body
Site Of Double-strand Break
BRCA1-B Complex
Site Of DNA Damage
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Nuclear Matrix
PML Body
Early Endosome Membrane
Nuclear Membrane
Molecular Function
DNA Binding
Protein Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Phosphorylation-dependent Protein Binding
Chromatin-protein Adaptor Activity
DNA Binding
Transcription Coactivator Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Binding
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cobalt Ion Binding
Molecular Adaptor Activity
Ubiquitin-like Protein Ligase Activity
Biological Process
DNA Replication Checkpoint Signaling
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Metabolic Process
DNA Replication Initiation
DNA Repair
Double-strand Break Repair
Chromatin Organization
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To Ionizing Radiation
Mitotic DNA Replication Checkpoint Signaling
Homologous Recombination
Chromosome Organization
Double-strand Break Repair Via Classical Nonhomologous End Joining
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Broken Chromosome Clustering
Protein Localization To Site Of Double-strand Break
Response To Hypoxia
Positive Regulation Of Defense Response To Virus By Host
Immune System Process
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Protein Targeting
Protein Import Into Nucleus
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To UV
Response To Gamma Radiation
Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Fibroblast Migration
Negative Regulation Of Angiogenesis
Protein Sumoylation
Myeloid Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
PML Body Organization
Protein-containing Complex Localization
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-1 Production
Circadian Regulation Of Gene Expression
Negative Regulation Of Translation In Response To Oxidative Stress
Response To Cytokine
Protein Localization To Nucleus
Regulation Of Circadian Rhythm
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Entrainment Of Circadian Clock By Photoperiod
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Suppression Of Viral Release By Host
Innate Immune Response
Cell Fate Commitment
Establishment Of Protein Localization
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Retinoic Acid Receptor Signaling Pathway
Rhythmic Process
Protein Stabilization
Regulation Of Protein Metabolic Process
Maintenance Of Protein Location In Nucleus
Defense Response To Virus
Regulation Of Cell Cycle
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Regulation Of Cellular Localization
SMAD Protein Signal Transduction
Branching Involved In Mammary Gland Duct Morphogenesis
Protein-containing Complex Assembly
Regulation Of Biological Quality
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Interleukin-4
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Senescence
Oncogene-induced Cell Senescence
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Localization To Chromosome, Telomeric Region
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Double-strand Break Repair
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Regulation of TP53 Activity through Acetylation
Interferon gamma signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN localization
HCMV Early Events
Drugs
Arsenic trioxide
Diseases
Acute myeloid leukemia (AML)
GWAS
Iron status biomarkers (
19084217
)
Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) (
29899525
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Height (
20881960
25282103
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Insomnia symptoms (never/rarely vs. sometimes/usually) (
30804566
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Myopia (pathological) (
23049088
)
Paget's disease (
21623375
)
Physical activity (overall physical activity time) (
30531941
)
White blood cell count (
32888494
)
Interacting Genes
30 interacting genes:
ABL1
AKT1
ATM
BMPR2
BRIP1
CDC45
CHEK1
CIP2A
CLSTN1
E2F1
ESR1
GINS1
HUS1
NFYA
PML
POLE
PPHLN1
PPP1CC
RAD1
RAD9A
RAI1
RBBP8
SMARCAD1
TBC1D4
TCFL5
TEX11
TOP2B
UBR5
USP13
ZBTB17
111 interacting genes:
ADH1B
ANKRD2
ARID3A
ARNT
ATF2
ATXN1
AURKA
AXIN1
BANP
BCL2
BCL6
CASP8AP2
CCNT1
CDK1
CDK2
CDK6
CHEK2
CHFR
CREBBP
CSNK2A1
DAXX
EGFR
EIF4E
ELF4
EP300
ERCC6
FOS
FXR1
GATA1
GATA2
HDAC1
HDAC2
HDAC3
HHEX
HIPK2
HTT
KAT5
KAT6A
KLHL20
MAD1L1
MAPK11
MAPK14
MDM2
MED7
MXD1
MYB
MYC
NACC1
NCOA2
NCOR1
NCOR2
NFKB1
NR4A1
PAWR
PAXIP1
PCBD2
PIAS1
PIAS2
PIN1
PLAGL1
PLSCR1
POLR2E
PSMA3
RARA
RB1
RBX1
RELA
RNF125
RPL11
RXRA
SENP1
SENP2
SH3GL1
SIAH2
SIN3A
SIRT1
SKI
SMAD3
SNCA
SP1
SP100
SRF
STAT3
SUMO1
SUMO2
SUMO3
SUV39H1
SYNE2
TDG
TERF2IP
TGFBR1
TGFBR2
TGIF1
THRA
TOPBP1
TP53
TP63
TP73
TRIB3
TRIM24
TRIM27
TRIM69
UBC
UBE2I
UBE2U
UBE3A
USP11
USP2
ZBTB16
ZFYVE9
ZNF451
Entrez ID
11073
5371
HPRD ID
09678
00023
Ensembl ID
ENSG00000163781
ENSG00000140464
Uniprot IDs
A0A2R8YD63
A0AV47
A7E2X7
Q05BV8
Q92547
P29590
PDB IDs
1WF6
2XNH
2XNK
3AL2
3AL3
3JVE
3OLC
3PD7
3UEN
3UEO
6RML
6RMM
7CMZ
8OK2
1BOR
2MVW
2MWX
4WJN
4WJO
5YUF
6IMQ
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
8DJH
8DJI
8J25
8J2P
8YTC
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
Negative Regulation Of Cell Cycle
DNA Damage Response
Nucleic Acid Metabolic Process
Signal Transduction In Response To DNA Damage
Cellular Response To Stress
Nucleoplasm
DNA Repair
Negative Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Chromosome
Macromolecule Metabolic Process
Checkpoint Clamp Complex
Negative Regulation Of Mitotic Cell Cycle
DNA Double-strand Break Processing
Intracellular Signal Transduction
Nucleus
Chromosome Organization
Regulation Of Mitotic Cell Cycle
Reproductive Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Cell Cycle Process
Homologous Recombination
Response To Stress
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Fibroblast Proliferation
Regulation Of Cellular Response To Stress
DNA Recombination
Cellular Senescence
DNA Replication Checkpoint Signaling
Regulation Of RNA Biosynthetic Process
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Mitotic DNA Damage Checkpoint Signaling
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Mitotic DNA Integrity Checkpoint Signaling
Cellular Response To Ionizing Radiation
Response To Radiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Developmental Process Involved In Reproduction
Regulation Of RNA Metabolic Process
Regulation Of Fibroblast Proliferation
Regulation Of DNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nucleus
PML Body
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromatin Binding
DNA-binding Transcription Factor Binding
DNA-templated Transcription
Apoptotic Process
Transcription By RNA Polymerase II
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Cell Communication
Programmed Cell Death
Cell Death
Regulation Of Cell Cycle
Transcription Regulator Complex
Intracellular Signal Transduction
Chromatin
Regulation Of Multicellular Organismal Process
Regulation Of Cell Differentiation
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