TOPBP1 and NFYA

Number of citations of the paper that reports this interaction (PubMedID 21930790)
47

Data Source:
BioGRID (pull down)

		TOPBP1	NFYA
Description		DNA topoisomerase II binding protein 1	nuclear transcription factor Y subunit alpha
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Site Of Double-strand Break BRCA1-B Complex Site Of DNA Damage	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding Chromatin-protein Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication Initiation DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling Homologous Recombination Chromosome Organization Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Via Alternative Nonhomologous End Joining Broken Chromosome Clustering Protein Localization To Site Of Double-strand Break	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		30 interacting genes: ABL1 AKT1 ATM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 GINS1 HUS1 NFYA PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 SMARCAD1 TBC1D4 TCFL5 TEX11 TOP2B UBR5 USP13 ZBTB17	50 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 EP300 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TOPBP1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		11073	4800
HPRD ID		09678	01793
Ensembl ID		ENSG00000163781	ENSG00000001167
Uniprot IDs		A0A2R8YD63 A0AV47 A7E2X7 Q05BV8 Q92547	P23511
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM 7CMZ 8OK2	4AWL 6QMP 6QMQ 6QMS 8QU2 8QU3 8QU4
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Negative Regulation Of Cell Cycle DNA Damage Response Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleoplasm DNA Repair Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome Macromolecule Metabolic Process Checkpoint Clamp Complex Negative Regulation Of Mitotic Cell Cycle DNA Double-strand Break Processing Intracellular Signal Transduction Nucleus Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Process Homologous Recombination Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Response To Stress DNA Recombination Cellular Senescence DNA Replication Checkpoint Signaling Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of DNA Metabolic Process	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Transcription Cis-regulatory Region Binding DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Cellular Senescence Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Metabolic Process ER-nucleus Signaling Pathway
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