TOPBP1 and TCFL5

Number of citations of the paper that reports this interaction (PubMedID 17006541)
37

Data Source:
HPRD (in vivo)

		TOPBP1	TCFL5
Description		DNA topoisomerase II binding protein 1	transcription factor like 5
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Site Of Double-strand Break BRCA1-B Complex Site Of DNA Damage	Chromatin Male Germ Cell Nucleus Nucleus
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding Chromatin-protein Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication Initiation DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling Homologous Recombination Chromosome Organization Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Via Alternative Nonhomologous End Joining Broken Chromosome Clustering Protein Localization To Site Of Double-strand Break	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Spermatogenesis Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Obesity-related traits ( 23251661)
Interacting Genes		30 interacting genes: ABL1 AKT1 ATM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 GINS1 HUS1 NFYA PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 SMARCAD1 TBC1D4 TCFL5 TEX11 TOP2B UBR5 USP13 ZBTB17	2 interacting genes: TOPBP1 USF1
Entrez ID		11073	10732
HPRD ID		09678	05297
Ensembl ID		ENSG00000163781	ENSG00000101190
Uniprot IDs		A0A2R8YD63 A0AV47 A7E2X7 Q05BV8 Q92547	Q86TP4 Q9UL49
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM 7CMZ 8OK2
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Negative Regulation Of Cell Cycle DNA Damage Response Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleoplasm DNA Repair Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome Macromolecule Metabolic Process Checkpoint Clamp Complex Negative Regulation Of Mitotic Cell Cycle DNA Double-strand Break Processing Intracellular Signal Transduction Nucleus Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Process Homologous Recombination Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Response To Stress DNA Recombination Cellular Senescence DNA Replication Checkpoint Signaling Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of DNA Metabolic Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Glucose Mediated Signaling Pathway Late Viral Transcription Response To Radiation Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Viral Transcription BRCA1-B Complex Broken Chromosome Clustering Carbon Catabolite Regulation Of Transcription Carbohydrate Mediated Signaling Regulation Of Transcription By Glucose Double-strand Break Repair Via Alternative Nonhomologous End Joining Phosphorylation-dependent Protein Binding Mitotic DNA Replication Checkpoint Signaling Double-strand Break Repair Via Classical Nonhomologous End Joining Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Chromatin-protein Adaptor Activity DNA Replication Checkpoint Signaling Positive Regulation Of Blood Coagulation Protein Localization To Site Of Double-strand Break DNA Replication Initiation BHLH Transcription Factor Binding Positive Regulation Of Coagulation Mitotic G2 DNA Damage Checkpoint Signaling Cellular Response To Nutrient Homologous Recombination Site Of DNA Damage Condensed Nuclear Chromosome Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Positive Regulation Of Wound Healing Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Regulation Of Hemostasis Regulation Of Blood Coagulation Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Via Nonhomologous End Joining Mitotic DNA Damage Checkpoint Signaling Protein Serine/threonine Kinase Activator Activity Intracellular Glucose Homeostasis Identical Protein Binding Cellular Response To Insulin Stimulus Site Of Double-strand Break DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of G2/M Transition Of Mitotic Cell Cycle
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