TOPBP1 and GINS1

Number of citations of the paper that reports this interaction (PubMedID 23629628)
34

Data Source:
BioGRID (two hybrid)

		TOPBP1	GINS1
Description		DNA topoisomerase II binding protein 1	GINS complex subunit 1
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Site Of Double-strand Break BRCA1-B Complex Site Of DNA Damage	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding Chromatin-protein Adaptor Activity	Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication Initiation DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling Homologous Recombination Chromosome Organization Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Via Alternative Nonhomologous End Joining Broken Chromosome Clustering Protein Localization To Site Of Double-strand Break	Inner Cell Mass Cell Proliferation DNA Replication DNA Strand Elongation Involved In Mitotic DNA Replication
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (alkaline phosphatase) ( 22001757) Platelet count ( 32888494) Telomere length ( 30185882)
Interacting Genes		30 interacting genes: ABL1 AKT1 ATM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 GINS1 HUS1 NFYA PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 SMARCAD1 TBC1D4 TCFL5 TEX11 TOP2B UBR5 USP13 ZBTB17	2 interacting genes: TOP2A TOPBP1
Entrez ID		11073	9837
HPRD ID		09678	11067
Ensembl ID		ENSG00000163781	ENSG00000101003
Uniprot IDs		A0A2R8YD63 A0AV47 A7E2X7 Q05BV8 Q92547	A0A8Q3WLJ3 A0A8Q3WLK7 A0A8Q3WLL7 Q14691
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM 7CMZ 8OK2	2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Negative Regulation Of Cell Cycle DNA Damage Response Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleoplasm DNA Repair Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome Macromolecule Metabolic Process Checkpoint Clamp Complex Negative Regulation Of Mitotic Cell Cycle DNA Double-strand Break Processing Intracellular Signal Transduction Nucleus Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Process Homologous Recombination Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Response To Stress DNA Recombination Cellular Senescence DNA Replication Checkpoint Signaling Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of DNA Metabolic Process	Male Germ Cell Nucleus Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Broken Chromosome Clustering DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Chromosome Organization BRCA1-B Complex Apoptotic Chromosome Condensation DNA Topoisomerase Activity DNA Topological Change Embryonic Cleavage Double-strand Break Repair Via Alternative Nonhomologous End Joining Phosphorylation-dependent Protein Binding Mitotic DNA Replication Checkpoint Signaling Double-strand Break Repair Via Classical Nonhomologous End Joining Resolution Of Meiotic Recombination Intermediates DNA Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Damage Response DNA Binding, Bending DNA Conformation Change Female Meiotic Nuclear Division DNA Replication Checkpoint Signaling Chromatin-protein Adaptor Activity Chromatin Organization Protein Localization To Site Of Double-strand Break DNA Replication Initiation Nuclear Chromosome ATP-dependent Activity, Acting On DNA Positive Regulation Of Viral Genome Replication Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Homologous Recombination Sister Chromatid Segregation Site Of DNA Damage Protein Kinase C Binding Condensed Nuclear Chromosome Nuclear Chromosome Segregation Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Nonhomologous End Joining Meiosis I Cell Cycle Process Cellular Response To Stress Positive Regulation Of Viral Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Protein Serine/threonine Kinase Activator Activity Meiotic Nuclear Division
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