MYOC and ACTB

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		MYOC	ACTB
Gene Name		myocilin, trabecular meshwork inducible glucocorticoid response	actin, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome	Nuclear Chromatin Extracellular Space Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Axon Ribonucleoprotein Complex Cortical Cytoskeleton NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Protein Complex Extracellular Vesicular Exosome MLL5-L Complex Blood Microparticle
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Nitric-oxide Synthase Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Retina Homeostasis Chromatin Organization Protein Folding Movement Of Cell Or Subcellular Component Axon Guidance Blood Coagulation Substantia Nigra Development Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ATP-dependent Chromatin Remodeling Cellular Protein Metabolic Process Innate Immune Response Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 HATs acetylate histones VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Folding of actin by CCT/TriC Innate Immune System Cell junction organization Protein folding Formation of annular gap junctions Chromatin organization Gap junction trafficking Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes Signaling by VEGF Chaperonin-mediated protein folding Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A	138 interactors: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAP2 CAPZA1 CCT2 CCT4 CCT5 CCT8 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CSNK1A1 CSNK2B CTGF DMTN DNASE1 DSTN DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII GAPDH GNA12 GSN H2AFX HCK HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 KHDRBS1 LASP1 LGALS13 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MX1 MYO18B MYO1E MYOC NCALD NCF1 NCF2 NEBL NOS2 NRAP NSMAF NT5E P2RX7 PCYT1A PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN RAB4A RAC1 RAC2 RCC1 RPL10A S100A11 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTBN2 SSH1 SSH2 SSH3 STX4 SYNJ2BP TANC1 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TTR VHL VSNL1 WASF1 WASF2 WASF3 WDYHV1 XPO6
Entrez ID		4653	60
HPRD ID		03387	00032
Ensembl ID		ENSG00000034971	ENSG00000075624
Uniprot IDs		Q99972	B3KWQ3 P60709 Q1KLZ0
PDB IDs			3BYH 3D2U 3LUE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion	Regulation Of Cellular Component Organization Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Organelle Organization Regulation Of Cellular Component Size Developmental Process Cell Differentiation Anatomical Structure Development Cell Development Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Filament Polymerization Actin Filament Organization Positive Regulation Of Organelle Organization System Development Negative Regulation Of Actin Filament Polymerization Regulation Of Cell Morphogenesis Multicellular Organismal Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Protein Complex Assembly Regulation Of Cell Projection Assembly Cellular Component Assembly Cellular Process Movement Of Cell Or Subcellular Component Regulation Of Cell Projection Organization Regulation Of Lamellipodium Assembly Platelet Activation Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Complex Assembly Regulation Of Cellular Process Cell Morphogenesis Wound Healing Positive Regulation Of Cellular Component Biogenesis Response To Wounding Regulation Of Stress Fiber Assembly Hemostasis Response To Stimulus Cell Death Death Positive Regulation Of Stress Fiber Assembly Apoptotic Process Cell Projection Organization
Tagcloud ?		accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous	18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid
Tagcloud (Difference) ?		accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous	18s algorithms bestkeeper cancerous circumstances comparisons examining expressional fluctuated gapdh genorm geometric hspcb lipofectamine normalization normalized normfinder powerful qpcr ranking reagent reagents reference reffinder stably studying thirteen transfection valid
Tagcloud (Intersection) ?