MYOC and TKT

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		MYOC	TKT
Description		myocilin	transketolase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome	Nucleoplasm Cytoplasm Peroxisome Endoplasmic Reticulum Membrane Cytosol Nuclear Body Vesicle Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Magnesium Ion Binding Transketolase Activity Calcium Ion Binding Protein Binding Transferase Activity Transketolase Or Transaldolase Activity Thiamine Pyrophosphate Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Glyceraldehyde-3-phosphate Metabolic Process Regulation Of Growth Glyceraldehyde-3-phosphate Biosynthetic Process D-xylulose 5-phosphate Biosynthetic Process
Pathways			Insulin effects increased synthesis of Xylulose-5-Phosphate Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs			Copper
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	A body shape index ( 34021172) Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) QRS duration ( 27577874 27659466 30012220) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	8 interacting genes: CEBPA FNDC3B ITGB1BP2 LINC01554 MYOC SERPINB5 SQSTM1 TERF1
Entrez ID		4653	7086
HPRD ID		03387	06001
Ensembl ID		ENSG00000034971	ENSG00000163931
Uniprot IDs		A0A0S2Z421 Q99972	P29401 V9HWD9
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR	3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY 6HA3 6HAD 6RJB 8WA8 8WA9 8WAA
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	Fat Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Energy Homeostasis Receptor Tyrosine Kinase Binding Skeletal Muscle Hypertrophy Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Brown Fat Cell Proliferation Amphisome CHOP-C/EBP Complex
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