MYOC and RFC1

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYOC	RFC1
Description		myocilin	replication factor C subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Elg1 RFC-like Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity DNA-binding Transcription Factor Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication DNA Repair Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching
Drugs
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	Appendicular lean mass ( 33097823) Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	20 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC USP7 YWHAQ ZSCAN1
Entrez ID		4653	5981
HPRD ID		03387	00024
Ensembl ID		ENSG00000034971	ENSG00000035928
Uniprot IDs		A0A0S2Z421 Q99972	P35251
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR	2EBU 2K6G 2K7F 6VVO
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	DNA Damage Response Positive Regulation Of DNA-directed DNA Polymerase Activity Enzyme Binding Nucleoplasm Nucleus Cellular Response To Stress Response To Xenobiotic Stimulus Chromatin Binding Cyclin D1-CDK4 Complex P53 Binding Protein-containing Complex Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Response To Steroid Hormone Symbiont-mediated Disruption Of Host Cell PML Body Transcription Regulator Complex Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Transcription Cis-regulatory Region Binding Response To Tumor Necrosis Factor DNA Replication Factor C Complex Histone Deacetylase Binding Regulation Of Metabolic Process Response To Glucocorticoid Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Positive Regulation Of DNA Biosynthetic Process DNA Repair Condensed Nuclear Chromosome Ctf18 RFC-like Complex Response To Corticosteroid Response To UV Animal Organ Regeneration DNA Clamp Loader Activity Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Vitamin Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Suppression Of Viral Transcription Chromosome
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