MYOC and TIMP1

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYOC	TIMP1
Description		myocilin	TIMP metallopeptidase inhibitor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Protease Binding Enzyme Inhibitor Activity Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Cellular Response To Peptide Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway
Pathways			Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation TGFBR3 PTM regulation
Drugs
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	9 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5 UBC
Entrez ID		4653	7076
HPRD ID		03387	02371
Ensembl ID		ENSG00000034971	ENSG00000102265
Uniprot IDs		A0A0S2Z421 Q99972	P01033 Q6FGX5
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR	1D2B 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D 7S7L 7S7M
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	Cellular Response To UV-A Response To UV-A Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Metalloendopeptidase Activity Endopeptidase Activity Cellular Response To UV Cellular Response To Light Stimulus Metallopeptidase Activity Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Fibronectin Binding Extracellular Structure Organization Extracellular Matrix Organization Pigment Granule Maturation Extracellular Space Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity Response To Light Stimulus Response To Amyloid-beta Skeletal Muscle Hypertrophy Mitochondrion Cellular Response To Amino Acid Stimulus Regulation Of Cell Migration Mitotic DNA-templated DNA Replication Extracellular Matrix Regulation Of Cell Motility Response To Radiation Peptidase Activity Cellular Pigment Accumulation Regulation Of Locomotion Catabolic Process Cellular Response To Reactive Oxygen Species Mitotic DNA Replication Response To Amino Acid Positive Regulation Of Cellular Component Organization Cellular Pigmentation Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Catalytic Activity, Acting On DNA Proteolysis Extracellular Region Multivesicular Body, Internal Vesicle Isomerase Activity Clustering Of Voltage-gated Sodium Channels Cellular Response To Camptothecin Platelet Dense Granule Membrane Intramembranous Ossification
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