MYOC and SERPINF1

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYOC	SERPINF1
Description		myocilin	serpin family F member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Axon Extracellular Matrix Melanosome Neuronal Cell Body Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Kidney Development Short-term Memory Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Response To Peptide
Pathways
Drugs			Copper
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	Blood protein levels ( 30072576) Calcium levels ( 20705733)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	11 interacting genes: CSNK2A1 EPM2AIP1 IMPACT KDR LRP6 MLH1 MYOC NEDD4L PNPLA2 PTPN11 SGTB
Entrez ID		4653	5176
HPRD ID		03387	01408
Ensembl ID		ENSG00000034971	ENSG00000132386
Uniprot IDs		A0A0S2Z421 Q99972	A0A140VKF3 P36955
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR	1IMV
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	Regulation Of Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Membrane Depolarization Wnt Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Biological Quality Positive Regulation Of Catabolic Process Hsp90 Protein Binding Coreceptor Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Cellular Developmental Process Regulation Of Mitochondrial Depolarization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Focal Adhesion Assembly Frizzled Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Skeletal Muscle Hypertrophy Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Triglyceride Metabolic Process Regulation Of Cytoplasmic Translational Initiation In Response To Stress Receptor Tyrosine Kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Focal Adhesion Assembly Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Cell-substrate Junction Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma ERBB Signaling Pathway Neutral Lipid Metabolic Process Acylglycerol Metabolic Process Intestinal Epithelial Cell Migration TRC Complex Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Cellular Response To Hydrogen Sulfide Cell Differentiation Male Meiosis Chromosome Segregation MutLalpha Complex Cerebellar Cortex Formation
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