MYOC and PKLR

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		MYOC	PKLR
Gene Name		myocilin, trabecular meshwork inducible glucocorticoid response	pyruvate kinase, liver and RBC
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding	Magnesium Ion Binding Pyruvate Kinase Activity ATP Binding Potassium Ion Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Response To Hypoxia Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process ATP Biosynthetic Process Response To Nutrient Pathogenesis Response To Heat Response To Glucose Response To Lithium Ion Phosphorylation Endocrine Pancreas Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Small Molecule Metabolic Process Response To CAMP Response To Other Organism
Pathways
Drugs			Pyruvic acid 2-Phosphoglycolic Acid Fructose-1,6-Diphosphate
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Urate levels ( 23263486)
Protein-Protein Interactions		40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A	3 interactors: CLEC4G MYOC PCNA
Entrez ID		4653	5313
HPRD ID		03387	11841
Ensembl ID		ENSG00000034971	ENSG00000143627
Uniprot IDs		Q99972	P30613
PDB IDs			2VGB 2VGF 2VGG 2VGI 4IMA 4IP7
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion	Positive Regulation Of Deoxyribonuclease Activity Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway ERBB2 Signaling Pathway Leading Strand Elongation Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Translesion Synthesis Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Nucleotide-excision Repair, DNA Gap Filling Regulation Of Mitochondrial Depolarization Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Hypertrophy Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Neuron Maturation DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Negative Regulation Of Cell-matrix Adhesion Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Stress Fiber Assembly Myelination In Peripheral Nervous System Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nuclease Activity Response To Cadmium Ion Regulation Of Cell Junction Assembly Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Mismatch Repair Base-excision Repair
Tagcloud ?		accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous	adaptation ago altitude ancestry asian challenged coordinated cyp2e1 deedu du edar environments epas1 extreme han highlanders insight migrated mongolian mongolians neighboring plateau pparg qinghai steppes tianjiao1 tibetan tibetans trait
Tagcloud (Difference) ?		accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous	adaptation ago altitude ancestry asian challenged coordinated cyp2e1 deedu du edar environments epas1 extreme han highlanders insight migrated mongolian mongolians neighboring plateau pparg qinghai steppes tianjiao1 tibetan tibetans trait
Tagcloud (Intersection) ?