MYOC and COL3A1

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		MYOC	COL3A1
Gene Name		myocilin, trabecular meshwork inducible glucocorticoid response	collagen, type III, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Skeletal System Development Receptor-mediated Endocytosis Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Heart Development Aging Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Extracellular Fibril Organization Skin Development Digestive Tract Development Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Neuron Migration
Pathways			Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A	12 interactors: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1
Entrez ID		4653	1281
HPRD ID		03387	00365
Ensembl ID		ENSG00000034971	ENSG00000168542
Uniprot IDs		Q99972	P02461
PDB IDs			2V53 3DMW 4AE2 4AEJ 4AK3 4GYX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Response To Wounding Regulation Of Cellular Component Movement Regulation Of Cellular Component Organization Platelet Degranulation Organ Development Positive Regulation Of Epithelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Organ Morphogenesis Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Wound Healing Regulation Of Epithelial Cell Proliferation Response To Growth Factor Multicellular Organismal Development Negative Regulation Of Phosphatidylinositol Biosynthetic Process Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Secretion Regulation Of Epithelial Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Developmental Process ERBB Signaling Pathway Blood Coagulation Collagen-activated Signaling Pathway Negative Regulation Of Phospholipid Biosynthetic Process System Development Positive Regulation Of Cell Proliferation Hemostasis Platelet Activation Positive Regulation Of Endothelial Cell Migration Neurotrophin TRK Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Secretion By Cell Neurotrophin Signaling Pathway Bone Development Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Anatomical Structure Development Positive Regulation Of Protein Kinase B Signaling
Tagcloud ?		accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous	abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel
Tagcloud (Difference) ?		accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous	abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel
Tagcloud (Intersection) ?