MYOC and ITGA7

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
HPRD (two hybrid)

		MYOC	ITGA7
Description		myocilin	integrin subunit alpha 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome	Plasma Membrane Integrin Complex Cell Surface Membrane
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Protein Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Leukocyte Migration Cell-cell Adhesion
Pathways			Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans
Drugs
Diseases		Primary open angle glaucoma	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	5 interacting genes: CHRNA1 FHL2 FHL3 HTRA2 MYOC
Entrez ID		4653	3679
HPRD ID		03387	02761
Ensembl ID		ENSG00000034971	ENSG00000135424
Uniprot IDs		A0A0S2Z421 Q99972	J3KNV4 Q13683
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	Osteoblast Differentiation Atrial Cardiac Muscle Cell Development Z Disc Mitochondrial Intermembrane Space Skeletal Muscle Hypertrophy Pentacyclic Triterpenoid Metabolic Process Negative Regulation Of Type 2 Mitophagy Negative Regulation Of Intracellular Signal Transduction Muscle Cell Cellular Homeostasis Acetylcholine Binding Muscle System Process Acetylcholine Receptor Activity Regulation Of Cell Communication Skeletal Muscle Tissue Growth Synaptic Transmission, Cholinergic Musculoskeletal Movement Regulation Of Membrane Potential Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Signaling Acetylcholine-gated Channel Complex Negative Regulation Of Signal Transduction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Heart Trabecula Formation Focal Adhesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Calcium-mediated Signaling Transcription Factor Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Membrane Depolarization Node Of Ranvier ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Rho Protein Signal Transduction ERBB3 Signaling Pathway Neuronal Ion Channel Clustering ERBB2 Signaling Pathway Myosin Light Chain Binding Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Depolarization Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Myelination In Peripheral Nervous System Positive Regulation Of Execution Phase Of Apoptosis Response To Herbicide Mitochondrial Protein Catabolic Process Ubiquitin Ligase Inhibitor Activity CD40 Receptor Complex Serine-type Endopeptidase Complex Negative Regulation Of Mitophagy Execution Phase Of Apoptosis
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