MYBPC3 and CAPN1

Number of citations of the paper that reports this interaction (PMID 12358155)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYBPC3	CAPN1
Gene Name		myosin binding protein C, cardiac	calpain 1, (mu/I) large subunit
Image
Gene Ontology Annotations	Cellular Component	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere A Band	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	ATPase Activator Activity Actin Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Heart Rate Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Muscle Filament Sliding Myosin Filament Assembly Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process
Pathways		Striated Muscle Contraction	Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CAPN1 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN	50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM
Entrez ID		4607	823
HPRD ID		02980	00253
Ensembl ID		ENSG00000134571	ENSG00000014216
Uniprot IDs		A5YM48 Q14896	B2RDI5 B4DWH5 P07384
PDB IDs		1GXE 1PD6 2AVG 2K1M 2V6H 3CX2	1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Actin Filament-based Movement Actomyosin Structure Organization Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Platelet Activation Uropod Organization Establishment Of Meiotic Spindle Localization Myosin Filament Assembly Establishment Of T Cell Polarity Respiratory Burst Involved In Defense Response Skeletal Muscle Atrophy Response To Yeast Muscle Contraction Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Killing By Host Of Symbiont Cells Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Muscle System Process Skeletal Muscle Adaptation Hydrogen Peroxide Biosynthetic Process Meiotic Spindle Organization Muscle Cell Differentiation Respiratory Burst Receptor Catabolic Process Negative Regulation Of Smooth Muscle Contraction Adult Heart Development Superoxide Anion Generation Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Neutrophil Mediated Immunity Blood Coagulation Hemostasis Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Cardiac Myofibril Assembly Killing Of Cells Of Other Organism Proteolysis Cardiac Muscle Hypertrophy Mitotic Chromosome Condensation	Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress
Tagcloud ?		11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?