MYBPC3

Name	myosin binding protein C3
Structure
Interactors	8 interactors: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN
GO Annotations	Cellular Component	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere M Band A Band Myosin Filament Cardiac Myofibril
	Molecular Function	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Cardiac Muscle Cell Contraction
Pathways	Striated Muscle Contraction
Diseases	Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS	Alcohol consumption ( 31358974 ) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Experiencing mood swings ( 29500382 ) Fruit consumption ( 32066663 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Intraocular pressure ( 30054594 ) Loneliness ( 29970889 ) Loneliness (MTAG) ( 29970889 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Monocyte count ( 32888494 ) Multiple sclerosis ( 31604244 ) Neuroticism ( 29255261 ) Pulse pressure ( 30578418 ) Refractive error ( 32231278 ) Thrombin generation potential phenotypes ( 24357727 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Entrez ID	4607
HPRD ID	02980
Ensembl ID	ENSG00000134571
Uniprot IDs	A5YM48 Q14896
PDB IDs	1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T 7LRG 7TIJ 7TIT 7TJ7 8G4L
GO Terms Enriched among Interactors ?	M Band Cytoplasm Uropod Organization Actin-mediated Cell Contraction Cortical Granule Exocytosis Actin Filament-based Movement Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Neutrophil-mediated Killing Of Fungus Cytoplasmic Side Of Plasma Membrane Myosin II Filament Actomyosin Structure Organization Skeletal Muscle Myosin Thick Filament Assembly Bundle Of His Cell To Purkinje Myocyte Communication Neutrophil-mediated Killing Of Gram-positive Bacterium Calpain Complex Somatic Muscle Development Actomyosin Contractile Ring Myosin Filament Assembly Z Disc Phagolysosome Mammary Gland Involution Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Peptidyl-serine Autophosphorylation Skeletal Muscle Atrophy NMDA Selective Glutamate Receptor Signaling Pathway Actin Filament Binding Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Calmodulin Binding Establishment Of T Cell Polarity Detection Of Muscle Stretch Muscle Contraction Striated Muscle Thin Filament Telethonin Binding Skeletal Muscle Thin Filament Assembly Defense Response To Other Organism Diapedesis Innate Immune Response Defense Response To Symbiont Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Respiratory Burst Involved In Defense Response Cellular Response To Testosterone Stimulus