MYBPC3 and TNNI3K

Number of citations of the paper that reports this interaction (PubMedID 12721663)
0

Data Source:
HPRD (two hybrid)

		MYBPC3	TNNI3K
Description		myosin binding protein C3	TNNI3 interacting kinase
Image
GO Annotations	Cellular Component	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere M Band A Band Myosin Filament Cardiac Myofibril	Nucleus Cytoplasm
	Molecular Function	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Cardiac Muscle Cell Contraction	Regulation Of Heart Rate Protein Phosphorylation Peptidyl-serine Autophosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction
Pathways		Striated Muscle Contraction
Drugs			Fostamatinib
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Alcohol consumption ( 31358974) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Experiencing mood swings ( 29500382) Fruit consumption ( 32066663) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Intraocular pressure ( 30054594) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Neuroticism ( 29255261) Pulse pressure ( 30578418) Refractive error ( 32231278) Thrombin generation potential phenotypes ( 24357727) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 23669352 28892062 26426971 28448500 20935630) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143 33045005) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		8 interacting genes: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN	8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3
Entrez ID		4607	51086
HPRD ID		02980	18208
Ensembl ID		ENSG00000134571	ENSG00000116783
Uniprot IDs		A5YM48 Q14896	Q59H18
PDB IDs		1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T 7LRG 7TIJ 7TIT 7TJ7 8G4L	4YFF 4YFI 6B5J 7MGJ 7MGK
Enriched GO Terms of Interacting Partners?		M Band Cytoplasm Uropod Organization Actin-mediated Cell Contraction Cortical Granule Exocytosis Actin Filament-based Movement Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Neutrophil-mediated Killing Of Fungus Cytoplasmic Side Of Plasma Membrane Myosin II Filament Actomyosin Structure Organization Skeletal Muscle Myosin Thick Filament Assembly Bundle Of His Cell To Purkinje Myocyte Communication Neutrophil-mediated Killing Of Gram-positive Bacterium Calpain Complex Somatic Muscle Development Actomyosin Contractile Ring Myosin Filament Assembly Z Disc Phagolysosome Mammary Gland Involution Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Peptidyl-serine Autophosphorylation Skeletal Muscle Atrophy NMDA Selective Glutamate Receptor Signaling Pathway Actin Filament Binding Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Calmodulin Binding Establishment Of T Cell Polarity Detection Of Muscle Stretch Muscle Contraction Striated Muscle Thin Filament Telethonin Binding Skeletal Muscle Thin Filament Assembly Defense Response To Other Organism Diapedesis Innate Immune Response Defense Response To Symbiont Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Respiratory Burst Involved In Defense Response Cellular Response To Testosterone Stimulus	Sarcomere Myosin Binding Cardiac Muscle Contraction Muscle Contraction Mesenchyme Migration Cardiac Muscle Tissue Morphogenesis Muscle System Process Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Cardiac Myofibril Striated Muscle Contraction Actin-myosin Filament Sliding Heart Contraction Heart Process Actin-mediated Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Icosatetraenoic Acid Binding C Zone Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions GAF Domain Binding Filopodium Cell Body Regulation Of Cardiac Muscle Contraction Actin Filament Actin Filament-based Process Tissue Morphogenesis Oleic Acid Binding Regulation Of Striated Muscle Contraction Blood Microparticle Actomyosin Structure Organization Positive Regulation Of Long-chain Fatty Acid Import Into Cell Acetyl-CoA C-myristoyltransferase Activity Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Regulation Of Muscle Filament Sliding Striated Muscle Myosin Thick Filament Cardiac Troponin Complex Troponin C Binding Cytosol Acetyl-CoA C-acyltransferase Activity Troponin T Binding Cytoplasmic Actin-based Contraction Involved In Cell Motility Long-chain Fatty Acid Binding Regulation Of Phosphatidylcholine Biosynthetic Process System Process Acetyl-CoA C-acetyltransferase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of Muscle Contraction Lamellipodium Enoyl-CoA Hydratase Activity
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