MYBPC3 and NCF1

Number of citations: 0 (PubMedID 16052631)
Data Source: BioGRID (two hybrid)

		MYBPC3	NCF1
Name		myosin binding protein C3	neutrophil cytosolic factor 1
Structure
GO Annotations	Cellular Component	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere M Band A Band Myosin Filament Cardiac Myofibril	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Cardiac Muscle Cell Contraction	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process
Pathways		Striated Muscle Contraction	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		None	Dextromethorphan
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Alcohol consumption ( 31358974 ) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Experiencing mood swings ( 29500382 ) Fruit consumption ( 32066663 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Intraocular pressure ( 30054594 ) Loneliness ( 29970889 ) Loneliness (MTAG) ( 29970889 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Monocyte count ( 32888494 ) Multiple sclerosis ( 31604244 ) Neuroticism ( 29255261 ) Pulse pressure ( 30578418 ) Refractive error ( 32231278 ) Thrombin generation potential phenotypes ( 24357727 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	Systemic lupus erythematosus ( 33493351 )
Interacting Genes		8 interacting genes: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN	29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		4607	653361
HPRD ID		02980	Not available
Ensembl ID		ENSG00000134571	ENSG00000158517
Uniprot IDs		A5YM48 Q14896	P14598
PDB IDs		1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T 7LRG 7TIJ 7TIT 7TJ7 8G4L	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ
GO Terms Enriched among Interactors		M Band Cytoplasm Uropod Organization Actin-mediated Cell Contraction Cortical Granule Exocytosis Actin Filament-based Movement Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Neutrophil-mediated Killing Of Fungus Cytoplasmic Side Of Plasma Membrane Myosin II Filament Actomyosin Structure Organization Skeletal Muscle Myosin Thick Filament Assembly Bundle Of His Cell To Purkinje Myocyte Communication Neutrophil-mediated Killing Of Gram-positive Bacterium Calpain Complex Somatic Muscle Development Actomyosin Contractile Ring Myosin Filament Assembly Z Disc Phagolysosome Mammary Gland Involution Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Peptidyl-serine Autophosphorylation Skeletal Muscle Atrophy NMDA Selective Glutamate Receptor Signaling Pathway Actin Filament Binding Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Calmodulin Binding Establishment Of T Cell Polarity Detection Of Muscle Stretch Muscle Contraction Striated Muscle Thin Filament Telethonin Binding Skeletal Muscle Thin Filament Assembly Defense Response To Other Organism Diapedesis Innate Immune Response Defense Response To Symbiont Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Respiratory Burst Involved In Defense Response Cellular Response To Testosterone Stimulus	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development