MYBPC3 and MYH9

Number of citations: 13 (PubMedID 352343)
Data Source: HPRD (in vitro, in vivo)

		MYBPC3	MYH9
Name		myosin binding protein C3	myosin heavy chain 9
Structure
GO Annotations	Cellular Component	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere M Band A Band Myosin Filament Cardiac Myofibril	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Golgi Apparatus Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Brush Border Adherens Junction Focal Adhesion Cell Cortex COP9 Signalosome Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Myosin Complex Myosin II Complex Nuclear Body Cortical Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Myosin Filament Protein-containing Complex Actomyosin Cortical Granule Extracellular Exosome Myosin II Filament Supramolecular Fiber
	Molecular Function	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity RNA Binding Cytoskeletal Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding
	Biological Process	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Cardiac Muscle Cell Contraction	Meiotic Spindle Organization Cell Morphogenesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Cytoskeleton Organization Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Lysosome Localization Cytokinetic Process Uropod Organization Regulation Of Actin Filament-based Process Endodermal Cell Differentiation Blood Vessel Endothelial Cell Migration Regulated Exocytosis Symbiont Entry Into Host Cell Cell Motility Leukocyte Migration Establishment Of Meiotic Spindle Localization Cytoplasmic Actin-based Contraction Involved In Cell Motility Cortical Granule Exocytosis Platelet Aggregation Cell-cell Adhesion Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair
Pathways		Striated Muscle Contraction	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis Signaling by ALK fusions and activated point mutants
Drugs		None	Artenimol
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)	MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant
GWAS		Alcohol consumption ( 31358974 ) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Experiencing mood swings ( 29500382 ) Fruit consumption ( 32066663 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Intraocular pressure ( 30054594 ) Loneliness ( 29970889 ) Loneliness (MTAG) ( 29970889 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Monocyte count ( 32888494 ) Multiple sclerosis ( 31604244 ) Neuroticism ( 29255261 ) Pulse pressure ( 30578418 ) Refractive error ( 32231278 ) Thrombin generation potential phenotypes ( 24357727 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	Diabetic kidney disease ( 26305897 ) End-stage renal disease (non-diabetic) ( 20532800 ) Glomerulosclerosis ( 20668430 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference ( 30108283 ) Language performance in older adults (adjusted for episodic memory) ( 28577822 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Optic nerve measurement (rim area) ( 20395239 ) Platelet count ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		8 interacting genes: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN	31 interacting genes: ANXA1 ASCC2 ATG9B CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 FXR1 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 NUDCD2 OVGP1 PPP2CA PTPN6 RAC1 RNF10 S100A4 SNCA TTN TUFM UBE2I WEE2-AS1 YWHAZ
Entrez ID		4607	4627
HPRD ID		02980	01177
Ensembl ID		ENSG00000134571	ENSG00000100345
Uniprot IDs		A5YM48 Q14896	P35579
PDB IDs		1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T 7LRG 7TIJ 7TIT 7TJ7 8G4L	2LNK 3ZWH 4CFQ 4CFR 4ETO
GO Terms Enriched among Interactors		M Band Cytoplasm Uropod Organization Actin-mediated Cell Contraction Cortical Granule Exocytosis Actin Filament-based Movement Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Neutrophil-mediated Killing Of Fungus Cytoplasmic Side Of Plasma Membrane Myosin II Filament Actomyosin Structure Organization Skeletal Muscle Myosin Thick Filament Assembly Bundle Of His Cell To Purkinje Myocyte Communication Neutrophil-mediated Killing Of Gram-positive Bacterium Calpain Complex Somatic Muscle Development Actomyosin Contractile Ring Myosin Filament Assembly Z Disc Phagolysosome Mammary Gland Involution Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Peptidyl-serine Autophosphorylation Skeletal Muscle Atrophy NMDA Selective Glutamate Receptor Signaling Pathway Actin Filament Binding Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Calmodulin Binding Establishment Of T Cell Polarity Detection Of Muscle Stretch Muscle Contraction Striated Muscle Thin Filament Telethonin Binding Skeletal Muscle Thin Filament Assembly Defense Response To Other Organism Diapedesis Innate Immune Response Defense Response To Symbiont Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Respiratory Burst Involved In Defense Response Cellular Response To Testosterone Stimulus	Structural Constituent Of Muscle Myosin Filament Actomyosin Structure Organization M Band Actin Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Skeletal Muscle Organ Development Cytoplasm Striated Muscle Myosin Thick Filament Positive Regulation Of Signal Transduction Myofibril Assembly Extraocular Skeletal Muscle Development Cytosol Organelle Organization Myosin Heavy Chain Binding Calcium Ion Binding Positive Regulation Of Transport Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Membraneless Organelle Assembly Positive Regulation Of Protein Secretion Supramolecular Fiber Intracellular Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase A Signaling Regulation Of Microtubule Polymerization Positive Regulation Of Secretion Cytoskeleton Organization Cell Cortex Regulation Of Transport Cardiac Myofibril Assembly Inflammatory Response Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Secretion By Cell Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Glutamatergic Synapse Actin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Vesicle Fusion Regulation Of Secretion Regulation Of Microtubule Polymerization Or Depolymerization