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AFDN and RAP1A
Number of citations of the paper that reports this interaction (PubMedID
10922060
)
41
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
AFDN
RAP1A
Description
afadin, adherens junction formation factor
RAP1A, member of RAS oncogene family
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Nuclear Speck
Cell Junction
Cell-cell Contact Zone
Pore Complex
Tight Junction
Anchoring Junction
Cytoplasm
Endosome
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Specific Granule Membrane
Neuron Projection
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Sperm Midpiece
Presynapse
Glutamatergic Synapse
Molecular Function
Protein Binding
Small GTPase Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Nucleotide Binding
GTPase Activity
G Protein Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Small GTPase Binding
Protein-containing Complex Binding
Biological Process
Cell Adhesion
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Gene Expression
Positive Regulation Of Cell-cell Adhesion
Cell Differentiation
Negative Regulation Of Cell Migration
Regulation Of Protein Localization
Cell Junction Organization
Cell-cell Adhesion Mediated By Cadherin
Pore Complex Assembly
Establishment Of Protein Localization To Plasma Membrane
Bicellular Tight Junction Assembly
Establishment Of Endothelial Intestinal Barrier
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Signal Transduction
Small GTPase-mediated Signal Transduction
Nervous System Development
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Synaptic Vesicle Exocytosis
Rap Protein Signal Transduction
Negative Regulation Of Collagen Biosynthetic Process
Nerve Growth Factor Signaling Pathway
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of D-glucose Import
Positive Regulation Of Phagocytosis
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Response To Antineoplastic Agent
Liver Regeneration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Cell Junction Assembly
Cellular Response To Forskolin
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Pathways
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS
Number of alcoholic drinks required to feel an effect (long-term average) (
31270906
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Crohn's disease (
30500874
32581322
)
High altitude adaptation (
28373541
)
Lymphocyte count (
32888494
)
Osteoporosis-related phenotypes (
20548944
)
Interacting Genes
39 interacting genes:
BCR
CTNNA1
DSCAM
EPHA7
EPHB2
EPHB3
EPHB6
F11R
HRAS
JAG1
LMO2
MRAS
NECTIN1
NECTIN2
NECTIN3
NECTIN4
NRXN1
NRXN2
NRXN3
PFN1
PICK1
RALGDS
RAP1A
RAP1GAP
RAP2A
RIN1
RIT1
RIT2
RNF10
RRAS
RRAS2
SMAD2
SORBS1
SORBS2
SSX2IP
TJP1
USP9X
YWHAB
YWHAG
43 interacting genes:
AFDN
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
ELOA
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
HSPA4
KRIT1
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA2
SMARCA4
TNFRSF10C
Entrez ID
4301
5906
HPRD ID
01164
01545
Ensembl ID
ENSG00000130396
ENSG00000116473
Uniprot IDs
A0A1P7ZIN0
A0A804HJ20
A8MQ02
G1UI22
J3KN01
P55196
A8KAH9
P62834
PDB IDs
1T2M
1XZ9
2AIN
2EXG
5A6C
7QCR
1C1Y
1GUA
3KUC
4KVG
Enriched GO Terms of Interacting Partners
?
Signal Transduction
GDP Binding
Regulation Of Cell Junction Assembly
Plasma Membrane
Small GTPase-mediated Signal Transduction
Cell Adhesion
Ras Protein Signal Transduction
Cell-cell Adhesion
Cell Adhesion Molecule Binding
Membrane
Regulation Of Synapse Assembly
Adherens Junction
G Protein Activity
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Anchoring Junction
Ephrin Receptor Activity
Regulation Of Cell Projection Organization
Transmembrane-ephrin Receptor Activity
Neuron Projection Guidance
Axon Guidance
Protein Localization To Cell Junction
GTPase Activity
Plasma Membrane Bounded Cell Projection Organization
Cell Junction Organization
Neuroligin Family Protein Binding
Synapse
Regulation Of Cellular Component Organization
Cell Junction Assembly
Modulation Of Chemical Synaptic Transmission
Regulation Of Cell Communication
Regulation Of Signaling
Postsynaptic Membrane Assembly
Intracellular Signaling Cassette
Regulation Of Synapse Organization
Focal Adhesion
Negative Regulation Of Cellular Component Organization
Apical Junction Complex
Regulation Of Locomotion
Zonula Adherens
Presynaptic Membrane
Cell Projection Organization
Postsynaptic Membrane Organization
Dendrite
Regulation Of Cell Projection Assembly
Neuron Projection Development
GTP Binding
Axon Guidance Receptor Activity
Cell Adhesion Mediator Activity
Regulation Of Cell Motility
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
GTPase Regulator Activity
Ras Protein Signal Transduction
Small GTPase-mediated Signal Transduction
Guanyl-nucleotide Exchange Factor Activity
Signal Transduction
Intracellular Signaling Cassette
Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of GTPase Activity
Plasma Membrane
Establishment Of Endothelial Barrier
Endothelial Cell Development
Positive Regulation Of GTPase Activity
CD95 Death-inducing Signaling Complex
Positive Regulation Of Hydrolase Activity
Neurotrophin Signaling Pathway
Epithelial Cell Development
Rap Protein Signal Transduction
Regulation Of Microvillus Assembly
GTPase Binding
Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Cytosol
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cell Communication
Regulation Of Signaling
Small GTPase Binding
Nerve Growth Factor Signaling Pathway
Establishment Of Endothelial Intestinal Barrier
Death-inducing Signaling Complex Assembly
Diacylglycerol Binding
Regulation Of Programmed Cell Death
Regulation Of Catalytic Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
CAMP Binding
Fas Signaling Pathway
Protein-containing Complex Organization
Cytoplasm
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Developmental Process
Protein-containing Complex Assembly
GTPase Activator Activity
Regulation Of Cellular Component Organization
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Nucleosome Array Spacer Activity
Positive Regulation Of Microvillus Assembly
Regulation Of Cell Differentiation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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