AFDN and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 12590145)
0

Data Source:
HPRD (two hybrid, in vitro)

		AFDN	RAP1GAP
Description		afadin, adherens junction formation factor	RAP1 GTPase activating protein
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction	Golgi Membrane Cytoplasm Early Endosome Golgi Apparatus Cytosol Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Adaptive Immune Response Phagocytosis Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Cell-cell Adhesion Negative Regulation Of Microvillus Assembly Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways			Rap1 signalling RET signaling
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	18 interacting genes: AFDN BRAF CDK1 CSNK1G2 DSCR9 DYNC1I1 GNAZ LCOR MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A VPS26C ZBTB12
Entrez ID		4301	5909
HPRD ID		01164	02609
Ensembl ID		ENSG00000130396	ENSG00000076864
Uniprot IDs		A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196	P47736 X6R8W7
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules	Protein Phosphorylation Phosphorylation Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Exocytosis Kinase Activity Phosphate-containing Compound Metabolic Process Mitotic Nuclear Membrane Disassembly Regulation Of Neurotransmitter Secretion Nuclear Membrane Disassembly Membrane Disassembly Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Protein Localization Protein Localization To Site Of Double-strand Break Regulation Of Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Secretion By Cell Postsynaptic Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Positive Regulation Of Protein Modification Process Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Exocytosis Establishment Of Endothelial Barrier Chromosome Condensation Negative Regulation Of Secretion Positive Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion Spindle Microtubule Endothelial Cell Development Peptidyl-serine Phosphorylation Regulation Of Exocytosis Protein Modification Process Nuclear Membrane Organization Centrosome Cycle Sperm Midpiece Presynapse Intracellular Signal Transduction Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Phosphorylation Modulation Of Chemical Synaptic Transmission MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Stress Fiber Assembly
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