MLLT4 and EPHB3

Number of citations of the paper that reports this interaction (PMID 9707552)
37

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		MLLT4	EPHB3
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	EPH receptor B3
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Cell Junction Apical Part Of Cell	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cell Adhesion Molecule Binding	Ephrin Receptor Activity ATP Binding Axon Guidance Receptor Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Rap GTPase Activity Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier	Angiogenesis Urogenital System Development Axon Guidance Axonal Fasciculation Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Rac GTPase Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Cdc42 GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis
Pathways			EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Metabolite levels (5-HIAA) ( 23319000)
Protein-Protein Interactions		37 interactors: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NRXN1 NRXN2 NRXN3 PFN1 PICK1 PVRL1 PVRL2 PVRL3 PVRL4 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	9 interactors: CRK EFNB3 FYN GBE1 LNX1 MLLT4 NFRKB RASA1 RYK
Entrez ID		4301	2049
HPRD ID		01164	03502
Ensembl ID		ENSG00000130396	ENSG00000182580
Uniprot IDs		P55196	P54753
PDB IDs		1T2M 1XZ9 2AIN 2EXG	3P1I
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Developmental Process Cell Development Cell Projection Organization Signal Transduction Nervous System Development Axon Development Cellular Response To Stimulus Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Cell Part Morphogenesis System Development Cell Differentiation Neuron Differentiation Ras Protein Signal Transduction Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Neuron Projection Development Neuron Projection Morphogenesis Locomotion Cell Projection Morphogenesis Regulation Of Signaling Cell Junction Assembly Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Regulation Of Cellular Component Organization Cell Adhesion Chemotaxis Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To External Stimulus Adherens Junction Organization Cellular Component Assembly Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Regulation Of Synapse Assembly Cellular Response To Organic Substance Response To Organic Substance Learning	Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Peptidyl-tyrosine Phosphorylation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Development Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Regulation Of Ras GTPase Activity Regulation Of Cell Shape Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Ras Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Generation Of Neurons Regulation Of Signal Transduction Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Platelet Activation Negative Regulation Of Neuron Death Axon Choice Point Recognition Establishment Of Endothelial Intestinal Barrier Regulation Of GTPase Activity Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Neuron Apoptotic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Phagocytosis Cellular Response To Platelet-derived Growth Factor Stimulus
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	ascl2 cdh1 collapse compete corepressor crc demethylase deregulates disabling displaying emt encapsulation engages hdacs incompletely inducers intriguingly invasiveness lsd1 migratory palisading repress roadblock snail1 snail2 stemness tcf7l2 xenotransplants zeb1
Tagcloud (Difference) ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	ascl2 cdh1 collapse compete corepressor crc demethylase deregulates disabling displaying emt encapsulation engages hdacs incompletely inducers intriguingly invasiveness lsd1 migratory palisading repress roadblock snail1 snail2 stemness tcf7l2 xenotransplants zeb1
Tagcloud (Intersection) ?