MLLT4 and RIT1

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
HPRD (two hybrid)

		MLLT4	RIT1
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Ras-like without CAAX 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Cell Junction Apical Part Of Cell	Plasma Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cell Adhesion Molecule Binding	Protein Binding Calmodulin Binding GTP Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Rap GTPase Activity Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier	Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway
Pathways			Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Metabolite levels (5-HIAA) ( 23319000)	Conduct disorder (interaction) ( 18846501) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		37 interactors: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NRXN1 NRXN2 NRXN3 PFN1 PICK1 PVRL1 PVRL2 PVRL3 PVRL4 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	14 interactors: AP2A1 CUL3 IFRD1 KLHL12 LRIF1 MLLT4 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2
Entrez ID		4301	6016
HPRD ID		01164	10195
Ensembl ID		ENSG00000130396	ENSG00000143622
Uniprot IDs		P55196	Q92963
PDB IDs		1T2M 1XZ9 2AIN 2EXG
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Developmental Process Cell Development Cell Projection Organization Signal Transduction Nervous System Development Axon Development Cellular Response To Stimulus Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Cell Part Morphogenesis System Development Cell Differentiation Neuron Differentiation Ras Protein Signal Transduction Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Neuron Projection Development Neuron Projection Morphogenesis Locomotion Cell Projection Morphogenesis Regulation Of Signaling Cell Junction Assembly Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Regulation Of Cellular Component Organization Cell Adhesion Chemotaxis Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To External Stimulus Adherens Junction Organization Cellular Component Assembly Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Regulation Of Synapse Assembly Cellular Response To Organic Substance Response To Organic Substance Learning	Signal Transduction Signaling Cell Communication Primary MiRNA Processing Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nodal Signaling Pathway Regulation Of Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development COPII Vesicle Coating Anatomical Structure Development Transforming Growth Factor Beta Receptor Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA COPII-coated Vesicle Budding Pericardium Development Regulation Of Cell Proliferation Response To Stimulus Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Vesicle Targeting, To, From Or Within Golgi Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Gastrulation Developmental Process In Utero Embryonic Development Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Metabolic Process Posttranscriptional Gene Silencing Protein Monoubiquitination Vesicle Targeting Localization Within Membrane
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Difference) ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Intersection) ?