MLLT4 and NRXN3

Number of citations of the paper that reports this interaction (PMID 9707552)
37

Data Source:
HPRD (two hybrid)

		MLLT4	NRXN3
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	neurexin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Cell Junction Apical Part Of Cell	Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cell Adhesion Molecule Binding	Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Rap GTPase Activity Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier	Angiogenesis Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Synapse Maturation
Pathways
Drugs
Diseases
GWAS		Metabolite levels (5-HIAA) ( 23319000)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body mass index ( 20935630) Obesity ( 23563607 21552555) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist circumference ( 19557197)
Protein-Protein Interactions		37 interactors: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NRXN1 NRXN2 NRXN3 PFN1 PICK1 PVRL1 PVRL2 PVRL3 PVRL4 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	5 interactors: CASK MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		4301	9369
HPRD ID		01164	08989
Ensembl ID		ENSG00000130396
Uniprot IDs		P55196	Q9HDB5 Q9Y4C0
PDB IDs		1T2M 1XZ9 2AIN 2EXG
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Developmental Process Cell Development Cell Projection Organization Signal Transduction Nervous System Development Axon Development Cellular Response To Stimulus Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Cell Part Morphogenesis System Development Cell Differentiation Neuron Differentiation Ras Protein Signal Transduction Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Neuron Projection Development Neuron Projection Morphogenesis Locomotion Cell Projection Morphogenesis Regulation Of Signaling Cell Junction Assembly Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Regulation Of Cellular Component Organization Cell Adhesion Chemotaxis Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To External Stimulus Adherens Junction Organization Cellular Component Assembly Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Regulation Of Synapse Assembly Cellular Response To Organic Substance Response To Organic Substance Learning	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Terminal Button Organization Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Adhesion Synapse Assembly Regulation Of Ion Transmembrane Transport Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Postsynaptic Density Protein 95 Clustering Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Synapse Organization Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell-cell Signaling Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Synaptic Transmission Regulation Of Dendrite Development Cellular Component Assembly Cytoskeletal Matrix Organization At Active Zone
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?