AFDN and NRXN2

Number of citations of the paper that reports this interaction (PubMedID 9707552)
36

Data Source:
HPRD (two hybrid)

		AFDN	NRXN2
Description		afadin, adherens junction formation factor	neurexin 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction	Plasma Membrane Membrane Protein-containing Complex Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell Adhesion Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Assembly
Pathways			Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Gout ( 33832965) Lymphocyte count ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 29403010 30993211) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)
Interacting Genes		39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ
Entrez ID		4301	9379
HPRD ID		01164	11859
Ensembl ID		ENSG00000130396	ENSG00000110076
Uniprot IDs		A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196	A0A8I5KY42 P58401 Q9P2S2
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR	4NXR
Enriched GO Terms of Interacting Partners?		Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules	Neurexin Family Protein Binding Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Presynapse Assembly Neuron Cell-cell Adhesion Cell Junction Assembly Cell Adhesion Molecule Binding Presynapse Organization Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Dendritic Spine Development Asymmetric, Glutamatergic, Excitatory Synapse Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Development Terminal Button Organization Membrane Assembly Positive Regulation Of Synapse Assembly Postsynaptic Density Protein 95 Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Synapse Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Cell Junction Assembly Regulation Of Respiratory System Process Regulation Of Nervous System Process Positive Regulation Of Synaptic Transmission, GABAergic Cell Adhesion Positive Regulation Of Synaptic Transmission Regulation Of Nervous System Development Regulation Of Respiratory Gaseous Exchange Regulation Of Synapse Assembly Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Cell-cell Junction Organization Localization Within Membrane Postsynaptic Specialization Membrane Cell Junction Regulation Of Synaptic Transmission, GABAergic Tight Junction Postsynaptic Membrane Synapse Organization Positive Regulation Of Developmental Process
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