AFDN and NECTIN1

Number of citations of the paper that reports this interaction (PubMedID 10225955)
64

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		AFDN	NECTIN1
Description		afadin, adherens junction formation factor	nectin cell adhesion molecule 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction	Extracellular Region Plasma Membrane Adherens Junction Membrane Axon Dendrite Growth Cone Membrane Presynaptic Membrane Cell Projection Apical Junction Complex Cell-cell Contact Zone Synapse Presynaptic Active Zone Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Symbiont Entry Into Host Cell Camera-type Eye Morphogenesis Regulation Of Synapse Organization Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cochlea Morphogenesis Cell-cell Adhesion Protein Localization To Cell Junction
Pathways			Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR
Entrez ID		4301	5818
HPRD ID		01164	07200
Ensembl ID		ENSG00000130396	ENSG00000110400
Uniprot IDs		A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196	Q15223
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR	3ALP 3SKU 3U82 3U83 4FMF 4MYW
Enriched GO Terms of Interacting Partners?		Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules	Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Positive Regulation Of Lipase Activity Cell Adhesion Mediator Activity Adherens Junction Fibroblast Growth Factor Binding Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Symbiont Entry Into Host Cell Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Biological Process Involved In Interaction With Host Plasma Membrane Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Kinase Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Fibroblast Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Endochondral Bone Growth Biomineral Tissue Development Cell Adhesion Molecule Binding Branching Involved In Salivary Gland Morphogenesis Signal Transduction Positive Regulation Of Hydrolase Activity Bone Growth Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Tyrosine Kinase Activity Anchoring Junction Regulation Of Postsynapse Organization Cell Adhesion Mesenchymal Cell Proliferation Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Apical Junction Complex Cell-cell Adhesion Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Receptor Complex Identical Protein Binding Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Cell-cell Junction Positive Regulation Of Heart Growth Establishment Of Protein Localization To Membrane Tight Junction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
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