APRT

Name	adenine phosphoribosyltransferase
Structure
Interactors	5 interactors: APP IKBKG MLH1 SUMO2 TTC19
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Adenine Binding Adenine Phosphoribosyltransferase Activity Protein Binding AMP Binding Transferase Activity Glycosyltransferase Activity Heterocyclic Compound Binding
	Biological Process	Purine Ribonucleoside Salvage Adenine Salvage Grooming Behavior GMP Salvage IMP Salvage AMP Salvage Adenine Metabolic Process
Pathways	Neutrophil degranulation Purine salvage Defective APRT disrupts adenine salvage
Drugs	Adenine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5H-pyrrolo[3,2-d]pyrimidin-4-amine Citric acid
Diseases	Adenine phosphoribosyltransferase deficiency; 2,8-Dihydroxyadenine urolithiasis
GWAS	Hair color ( 26926045 )
Entrez ID	353
HPRD ID	00029
Ensembl ID	ENSG00000198931
Uniprot IDs	P07741
PDB IDs	1ORE 1ZN7 1ZN8 1ZN9 4X44 4X45 6FCH 6FCI 6FCL 6FD4 6FD5 6FD6 6HGP 6HGQ 6HGR 6HGS
GO Terms Enriched among Interactors ?	Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Response To Calcium Ion Cell Activation Involved In Immune Response Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Linear Polyubiquitin Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Protein Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Guanine/thymine Mispair Binding Homologous Chromosome Segregation