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APRT and MLH1
Number of citations of the paper that reports this interaction (PubMedID
20706999
)
0
Data Source:
BioGRID
(two hybrid)
APRT
MLH1
Description
adenine phosphoribosyltransferase
mutL homolog 1
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytoplasm
Cytosol
Secretory Granule Lumen
Extracellular Exosome
Condensed Chromosome
Condensed Nuclear Chromosome
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Chiasma
Late Recombination Nodule
Membrane
Nuclear Lumen
Mismatch Repair Complex
MutLalpha Complex
Molecular Function
Adenine Binding
Adenine Phosphoribosyltransferase Activity
Protein Binding
AMP Binding
Transferase Activity
Glycosyltransferase Activity
Heterocyclic Compound Binding
Nucleotide Binding
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP Hydrolysis Activity
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
ATP-dependent DNA Damage Sensor Activity
Biological Process
Purine Ribonucleoside Salvage
Adenine Salvage
Grooming Behavior
GMP Salvage
IMP Salvage
AMP Salvage
Adenine Metabolic Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Stress
DNA Damage Response
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Meiotic Metaphase I Homologous Chromosome Alignment
Meiotic Chromosome Segregation
Meiotic Telomere Clustering
Homologous Chromosome Segregation
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Meiotic Cell Cycle
Pathways
Neutrophil degranulation
Purine salvage
Defective APRT disrupts adenine salvage
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
Drugs
Adenine
5-O-phosphono-alpha-D-ribofuranosyl diphosphate
5H-pyrrolo[3,2-d]pyrimidin-4-amine
Citric acid
Diseases
Adenine phosphoribosyltransferase deficiency; 2,8-Dihydroxyadenine urolithiasis
Ovarian cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
Endometrial Cancer
GWAS
Hair color (
26926045
)
Alanine aminotransferase levels (
33547301
)
Autism spectrum disorder or schizophrenia (
28540026
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Platelet distribution width (
32888494
)
Proximal colorectal cancer (
33632709
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Interacting Genes
5 interacting genes:
APP
IKBKG
MLH1
SUMO2
TTC19
139 interacting genes:
-
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH2
MSH3
MSH4
MSH5
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
Entrez ID
353
4292
HPRD ID
00029
00390
Ensembl ID
ENSG00000198931
ENSG00000076242
Uniprot IDs
P07741
A0A087WX20
A0A669KAW3
A0AAQ5BGN3
A0AAQ5BGZ2
H0Y818
P40692
Q59EG3
PDB IDs
1ORE
1ZN7
1ZN8
1ZN9
4X44
4X45
6FCH
6FCI
6FCL
6FD4
6FD5
6FD6
6HGP
6HGQ
6HGR
6HGS
3RBN
4P7A
5U5P
6WBA
6WBB
6WBC
7M60
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Proteolysis
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Acetylcholine Receptor Activator Activity
Amyloid-beta Complex
PTB Domain Binding
Growth Cone Lamellipodium
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Positive Regulation Of Catabolic Process
Regulation Of Response To Calcium Ion
Cell Activation Involved In Immune Response
Amylin Binding
Regulation Of Proteolysis
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Response To Bacterium
Regulation Of Response To Endoplasmic Reticulum Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Meiotic Spindle Midzone Assembly
Meiotic Metaphase Chromosome Alignment
Male Meiosis Chromosome Segregation
MutLalpha Complex
Chiasma
Late Recombination Nodule
Meiotic Metaphase I Homologous Chromosome Alignment
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Linear Polyubiquitin Binding
Response To Norepinephrine
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Intermediate-density Lipoprotein Particle
Positive Regulation Of Protein Metabolic Process
Axon Midline Choice Point Recognition
Positive Regulation Of Protein Catabolic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Amyloid Fibril Formation
Cellular Response To Norepinephrine Stimulus
Growth Factor Receptor Binding
Main Axon
Astrocyte Activation Involved In Immune Response
Low-density Lipoprotein Particle Mediated Signaling
Guanine/thymine Mispair Binding
Homologous Chromosome Segregation
Mismatch Repair
Mismatched DNA Binding
ATP-dependent DNA Damage Sensor Activity
Cellular Response To Stress
Apoptotic Signaling Pathway
Response To Estradiol
DNA Damage Response
Dinucleotide Insertion Or Deletion Binding
Intrinsic Apoptotic Signaling Pathway
Response To Corticosteroid
DNA Repair
Mismatch Repair Complex
DNA Metabolic Process
Protein Binding
Response To Glucocorticoid
Damaged DNA Binding
Response To Hydrogen Peroxide
Mitotic DNA Damage Checkpoint Signaling
Nucleic Acid Metabolic Process
Response To Dexamethasone
Mitotic DNA Integrity Checkpoint Signaling
Somatic Cell DNA Recombination
Signal Transduction In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Response To Reactive Oxygen Species
MutSbeta Complex
Dinucleotide Repeat Insertion Binding
Response To Steroid Hormone
Nucleus
Response To Stress
Somatic Hypermutation Of Immunoglobulin Genes
DNA Recombination
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Fructose-bisphosphate Aldolase Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Single Guanine Insertion Binding
MutLalpha Complex
Response To Oxidative Stress
Cellular Response To Corticosteroid Stimulus
Mucus Secretion
Response To Radiation
Single-stranded DNA Binding
P53 Binding
Response To UV
Mitotic Intra-S DNA Damage Checkpoint Signaling
Signal Sequence Binding
Guanine/thymine Mispair Binding
Satellite DNA Binding
Somatic Diversification Of Immunoglobulins
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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