PLEKHO1 and AKT2

Number of citations of the paper that reports this interaction (PubMedID 17942896)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PLEKHO1	AKT2
Description		pleckstrin homology domain containing O1	AKT serine/threonine kinase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Membrane Ruffle Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Protein Stabilization Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Retinal Rod Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cell Motility
Pathways			Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation
Drugs			N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases			Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte count ( 32888494)
Interacting Genes		33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	43 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP
Entrez ID		51177	208
HPRD ID		12217	01262
Ensembl ID		ENSG00000023902	ENSG00000105221
Uniprot IDs		Q53GL0 Q5T4P9	B4DG79 P31751
PDB IDs		3AA1	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D 8Q61 9C1W
Enriched GO Terms of Interacting Partners?		Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response	Intracellular Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Hormone Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Nitric-oxide Synthase Regulator Activity Intracellular Signaling Cassette Regulation Of Innate Immune Response Cytosol Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Hormone Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Response To Insulin Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Chemical Homeostasis Low-density Lipoprotein Particle Regulation Of Vesicle-mediated Transport Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta Homeostatic Process Response To Peptide Hormone Endocytic Vesicle Lumen Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Response To Amyloid-beta Regulation Of Immune System Process Response To Stress Positive Regulation Of Signal Transduction Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Levels Regulation Of Protein Modification Process Protein Serine/threonine Kinase Binding Cholesterol Transfer Activity Regulation Of Defense Response
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