PLEKHO1 and LRP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHO1	LRP10
Description		pleckstrin homology domain containing O1	LDL receptor related protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane	Plasma Membrane Clathrin-coated Pit Membrane
	Molecular Function	Protein Binding	Low-density Lipoprotein Particle Receptor Activity Protein Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	Lipid Metabolic Process Lipid Transport Endocytosis Vesicle-mediated Transport Inner Ear Development
Pathways			Retinoid metabolism and transport
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Neutrophil count ( 32888494)
Interacting Genes		33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	23 interacting genes: C16orf92 CISD2 EBP FAM209A GGA3 GJB5 GOLM2 GORAB HTRA1 LMNA MGST3 MRPS18B NOTO PDCD1LG2 PLEKHO1 SLC10A1 SLC14A2 SLC71A2 SMIM1 ST6GALNAC6 TMEM179B TMEM237 TMEM243
Entrez ID		51177	26020
HPRD ID		12217	14311
Ensembl ID		ENSG00000023902	ENSG00000197324
Uniprot IDs		Q53GL0 Q5T4P9	Q7Z4F1
PDB IDs		3AA1
Enriched GO Terms of Interacting Partners?		Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response
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