PLEKHO1 and THSD7B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PLEKHO1	THSD7B
Name		pleckstrin homology domain containing O1	thrombospondin type 1 domain containing 7B
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Ruffle Membrane Muscle Cell Projection Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis Regulation Of Myoblast Fusion	Actin Cytoskeleton Organization
Pathways		None	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
GWAS		Bipolar disorder ( 31043756 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )	Albumin-globulin ratio ( 29403010 ) Aluminium levels ( 26025379 ) Daytime sleep phenotypes ( 27126917 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Liver enzyme levels (aspartate transaminase) ( 24124411 ) Machado-Joseph disease (age at onset) ( 32205469 ) Multiple system atrophy ( 27629089 ) Non-albumin protein levels ( 29403010 ) Non-small cell lung cancer ( 23144319 ) Pancreatic cancer ( 20686608 ) Problematic alcohol use ( 32451486 ) Prudent dietary pattern ( 28644415 ) Regular attendance at a gym or sports club ( 29970889 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking initiation ( 30617275 33082346 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Subcutaneous adipose tissue ( 22589738 ) Systolic blood pressure ( 30224653 ) Tooth agenesis (third molar) ( 24172245 ) Urinary albumin-to-creatinine ratio ( 26631737 ) Weight ( 28552196 )
Novel Interactors		7 novel interactors: ADAMTSL4 C1orf56 CDC42SE1 GOLPH3L RPRD2 SMG5 SYT11	None recorded
Interacting Genes		33 interacting genes: ADAM33 AKT1 AKT2 ARLN BNIP2 BRICD5 C10orf88 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB OGT PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	25 interacting genes: AQP6 ARL13B CISD2 DARS2 FAM209A FKBP7 GJA8 GPR101 GPR152 GPR37L1 KCNJ6 KIR3DL1 LYVE1 MTIF3 PEX12 PIGP PLEKHO1 RANBP10 SLC14A1 SLC30A8 SLC71A2 SPACA1 STOM SYT2 TMX2
Entrez ID		51177	80731
HPRD ID		12217	19009
Ensembl ID		ENSG00000023902	ENSG00000144229
Uniprot IDs		Q53GL0 Q5T4P9	Q9C0I4
PDB IDs		3AA1	Not available
GO Terms Enriched among Interactors		Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of Fatty Acid Transport Positive Regulation Of Translational Initiation Regulation Of Translational Initiation Protein Localization To Membrane Symbiont-mediated Disruption Of Host Cell PML Body Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Fatty Acid Transport Positive Regulation Of Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Glucose Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Lipid Transport Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Localization Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of D-glucose Import Positive Regulation Of JUN Kinase Activity Regulation Of Lipid Catabolic Process Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Translation Negative Regulation Of Transport TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Autophagy Toll-like Receptor 3 Signaling Pathway Myelin Maintenance Pattern Recognition Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response	Membrane