AXIN1 and LRP5

Number of citations of the paper that reports this interaction (PubMedID 11336703)
0

Data Source:
HPRD (in vivo)

		AXIN1	LRP5
Description		axin 1	LDL receptor related protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Cell Periphery Wnt Signalosome	Endoplasmic Reticulum Plasma Membrane Membrane Receptor Complex Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome
	Molecular Function	P53 Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding Protein Serine/threonine Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Coreceptor Activity Wnt-protein Binding Toxin Transmembrane Transporter Activity Wnt Receptor Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Nucleocytoplasmic Transport Apoptotic Process Sensory Perception Of Sound Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Wnt Signaling Pathway Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Post-anal Tail Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of JNK Cascade Axial Mesoderm Development Axial Mesoderm Formation Cell Development Negative Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Head Development Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Gastrulation With Mouth Forming Second Vasculature Development Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Glucose Catabolic Process Amino Acid Transport Endocytosis Nervous System Development Mesodermal Cell Migration Cholesterol Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Anterior/posterior Pattern Specification Gene Expression Wnt Signaling Pathway Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Limb Morphogenesis Extracellular Matrix-cell Signaling Cell Migration Involved In Gastrulation Cholesterol Homeostasis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Response To Peptide Hormone Small Molecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Blood Vessel Morphogenesis Bone Marrow Development Anatomical Structure Regression Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Bone Development Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Duct Morphogenesis Adipose Tissue Development Cell-cell Signaling Involved In Mammary Gland Development Establishment Of Blood-brain Barrier Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Biological Quality Cell-cell Adhesion Norrin Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by LRP5 mutants Signaling by RNF43 mutants
Drugs		1,4-Dithiothreitol
Diseases		Caudal duplication anomaly Hepatocellular carcinoma	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND) Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1) Osteoporosis-pseudoglioma syndrome (OPPG)
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)	Bone mineral density ( 18455228 24249740) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Femoral neck section modulus ( 30888730) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Hip index ( 34021172) Lumbar spine bone mineral density ( 22504420 29499414) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Monobrow ( 27182965)
Interacting Genes		91 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 FXR1 FXR2 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KAT5 KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RCHY1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSC1 TSGA10 UCHL5 USP10 USP7 UTP14A WSB1 ZBTB26 ZFYVE19	9 interacting genes: AXIN1 CAPRIN2 DKK1 FZD8 MESD MTDH SMAD9 THBS1 WNT1
Entrez ID		8312	4041
HPRD ID		04819	04616
Ensembl ID		ENSG00000103126	ENSG00000162337
Uniprot IDs		A0A0S2Z4R0 A0A0S2Z4S3 O15169	O75197
PDB IDs		1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK 7SXF 7SXG 7SXH 7SXJ 7Y1P 8RU3 8RU4 8VMG
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Cytoplasm Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Wnt Signalosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-catenin Destruction Complex Signal Transduction Beta-catenin Binding PML Body Positive Regulation Of Biosynthetic Process	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of CGMP-mediated Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Specification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of CGMP-mediated Signaling Regulation Of Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Heart Valve Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process CGMP-mediated Signaling Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process T Cell Differentiation In Thymus Mesoderm Formation Regulation Of Intracellular Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Fat Cell Differentiation Formation Of Primary Germ Layer Beta-catenin Destruction Complex Assembly Mesoderm Development Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation
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