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AXIN1 and SENP2
Number of citations of the paper that reports this interaction (PubMedID
11997515
)
69
Data Source:
HPRD
(in vitro)
AXIN1
SENP2
Description
axin 1
SUMO specific peptidase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Nucleus
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Nuclear Body
PML Body
Nuclear Membrane
Molecular Function
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
DeSUMOylase Activity
SUMO-specific Endopeptidase Activity
Biological Process
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Proteolysis
Heart Development
Protein Transport
Wnt Signaling Pathway
Protein Sumoylation
Protein Desumoylation
Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of DNA Endoreduplication
Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Transport
Regulation Of Macromolecule Metabolic Process
Trophoblast Giant Cell Differentiation
Labyrinthine Layer Development
Regulation Of Primary Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
SUMO is proteolytically processed
Drugs
1,4-Dithiothreitol
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Diastolic blood pressure (
27841878
28135244
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31015462
31152163
)
Height (
28552196
)
Hip circumference (
28552196
)
JT interval (
29874175
)
PR interval (
30046033
32439900
)
QRS duration (
30012220
)
Seborrheic dermatitis (
29203360
)
Systolic blood pressure (
26969751
27841878
)
Interacting Genes
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
40 interacting genes:
ACSF2
AGTRAP
APOC2
APOC4
APP
AR
ARL6IP1
ARMC12
AXIN1
CDCA5
CDK5RAP2
DAXX
ERCC6
FUNDC1
FZR1
HCCS
IKBKG
KASH5
KPNA1
KPNB1
LMNA
MYC
NACC1
NEDD4L
NUP153
OGT
PML
RANGAP1
RETREG3
RPRM
SDR16C5
STK38
SUMO1
SUMO2
SUMO3
SYNE4
TMEM239
TNFRSF10D
TPD52
TRIM63
Entrez ID
8312
59343
HPRD ID
04819
07002
Ensembl ID
ENSG00000103126
ENSG00000163904
Uniprot IDs
A0A0S2Z4R0
A0A0S2Z4S3
O15169
Q9HC62
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
1TGZ
1TH0
2IO0
2IO1
2IO2
2IO3
3ZO5
5AEK
Enriched GO Terms of Interacting Partners
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Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Sumoylation
Positive Regulation Of Proteolysis
Ubiquitin Protein Ligase Binding
Nuclear Transport
Nucleocytoplasmic Transport
Nuclear Pore
Regulation Of Proteolysis
Nuclear Membrane
Protein Modification By Small Protein Conjugation
Protein Localization To Nucleus
PML Body
Protein Tag Activity
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Protein Import Into Nucleus
Nuclear Envelope
Import Into Nucleus
Very-low-density Lipoprotein Particle
Chromatin Organization
Post-translational Protein Modification
Endoplasmic Reticulum Tubular Network
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Nuclear Localization Sequence Binding
High-density Lipoprotein Particle
Regulation Of Protein Catabolic Process
Ubiquitin-like Protein Ligase Binding
Positive Regulation Of Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intermediate-density Lipoprotein Particle
Nucleus Organization
Protein Binding
DNA Damage Response
Positive Regulation Of Protein Metabolic Process
Protein Localization To Organelle
Regulation Of Proteasomal Protein Catabolic Process
PML Body Organization
Chromatin Remodeling
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Apoptotic Process
Regulation Of Protein Localization
Molecular Condensate Scaffold Activity
Programmed Cell Death
Protein Modification Process
NLS-dependent Protein Nuclear Import Complex
Meiotic Nuclear Membrane Microtubule Tethering Complex
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Tagcloud (Intersection)
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