AXIN1 and UTP14A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AXIN1	UTP14A
Gene Name		axin 1	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Microtubule Cell Cortex Postsynaptic Density Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery	Nucleolus Small-subunit Processome
	Molecular Function	P53 Binding Signal Transducer Activity GTPase Activator Activity Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Enzyme Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity Ubiquitin Protein Ligase Binding Protein Complex Scaffold Identical Protein Binding Protein Homodimerization Activity Protein Self-association SMAD Binding Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Optic Placode Formation Positive Regulation Of Protein Phosphorylation Nucleocytoplasmic Transport Apoptotic Process Activation Of JUN Kinase Activity Determination Of Left/right Symmetry Sensory Perception Of Sound Cell Death Dorsal/ventral Axis Specification Positive Regulation Of Peptidyl-threonine Phosphorylation Forebrain Anterior/posterior Pattern Specification Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Olfactory Placode Formation Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Catenin Import Into Nucleus Post-anal Tail Morphogenesis Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Cellular Protein Complex Assembly Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Embryonic Eye Morphogenesis Axial Mesoderm Formation Negative Regulation Of Protein Metabolic Process Protein Homooligomerization Positive Regulation Of Ubiquitin-protein Transferase Activity Muscle Cell Development Canonical Wnt Signaling Pathway Embryonic Skeletal Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Cellular Response To Organic Cyclic Compound Genetic Imprinting Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Maturation Of SSU-rRNA
Pathways		misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling degradation of AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		43 interactors: AMER1 ANP32A APC BTRC CARM1 CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 GAK GNAS GSK3B JUP LMO2 LRP5 LRP6 MAP3K4 MYC MYOT NCK2 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 RNF111 RUNX2 SENP2 SH3GL1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 UTP14A	43 interactors: AKTIP APLP1 ARIH2 AXIN1 CCDC106 CCDC85B CEP70 CPE CSNK2A1 CSNK2B DLEU1 GADD45G HNRNPH3 HOOK2 HTT LAMTOR5 LDOC1 LSM3 NINL PDCD5 PDZK1IP1 PHF10 PRKCZ PSG1 PTEN PTPRS RABIF RGS1 RHOH RNF10 RPA2 RSRC1 SAT1 SMYD1 SSR1 TERF1 TINAGL1 TP53 TP53BP2 TRDMT1 VIM WDR33 ZNF24
Entrez ID		8312	10813
HPRD ID		04819	06712
Ensembl ID		ENSG00000103126	ENSG00000156697
Uniprot IDs		O15169	F8WD00 Q9BVJ6
PDB IDs		1DK8 1EMU 1O9U 3ZDI 4B7T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Regulation Of Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Tissue Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Metabolic Process Organ Morphogenesis Anatomical Structure Development System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Developmental Process Organ Development Multicellular Organismal Development Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus	Apoptotic Process Programmed Cell Death Cell Death Death Developmental Process Regulation Of Catalytic Activity Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Nervous System Development System Development Mitotic Cell Cycle Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Proliferation Negative Regulation Of Neurogenesis Regulation Of Cell Cycle Cytoplasmic Transport Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Mitotic Cell Cycle Checkpoint Central Nervous System Development Negative Regulation Of Cell Differentiation Cell Differentiation Negative Regulation Of Cell Development Regulation Of Phosphorylation Neurotransmitter Uptake
Tagcloud ?		aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Difference) ?		aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Intersection) ?