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AXIN1 and GAK
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
AXIN1
GAK
Description
axin 1
cyclin G associated kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Cytoplasm
Golgi Apparatus
Cytosol
Focal Adhesion
Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Anchoring Junction
Presynapse
Molecular Function
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Clathrin Binding
Cyclin Binding
Protein Folding Chaperone
Protein Serine Kinase Activity
Biological Process
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Folding
Receptor-mediated Endocytosis
Endoplasmic Reticulum Organization
Golgi Organization
Negative Regulation Of Neuron Projection Development
Synaptic Vesicle Uncoating
Protein Localization To Golgi Apparatus
Intracellular Transport
Clathrin Coat Assembly
Clathrin Coat Disassembly
Clathrin-dependent Endocytosis
Protein Localization To Plasma Membrane
Golgi To Lysosome Transport
Regulation Of Clathrin Coat Assembly
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis
Drugs
1,4-Dithiothreitol
Fostamatinib
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
A body shape index (
34021172
)
HDL cholesterol (
30275531
)
Mortality in sepsis (
27639821
)
Parkinson's disease (
20711177
32310270
27182965
25064009
22438815
21738487
21292315
)
Parkinson's disease (age of onset) (
30957308
)
Parkinson's disease (familial) (
18985386
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Primary biliary cholangitis (
26394269
)
Triglycerides (
30275531
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
14 interacting genes:
AP1M1
AP1M2
AP2M1
APP
AR
AXIN1
CCNG1
CDK5
CLTC
CREBBP
HSPA8
LRRK1
MFHAS1
USO1
Entrez ID
8312
2580
HPRD ID
04819
03631
Ensembl ID
ENSG00000103126
ENSG00000178950
Uniprot IDs
A0A0S2Z4R0
A0A0S2Z4S3
O15169
B4DS37
O14976
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
4C57
4C58
4C59
4O38
4Y8D
5Y7Z
5Y80
Enriched GO Terms of Interacting Partners
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Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
Intracellular Transport
Intracellular Protein Transport
Clathrin Adaptor Complex
Regulation Of Protein Localization
Clathrin Adaptor Activity
Acetylcholine Receptor Activator Activity
Negative Regulation Of Protein Localization
Cellular Localization
Establishment Of Localization In Cell
Low-density Lipoprotein Particle Receptor Binding
Regulation Of Protein Import
Trans-Golgi Network Membrane
Regulation Of Protein Localization To Plasma Membrane
Cytoplasmic Vesicle
Clathrin Coat Disassembly
Regulation Of Protein Localization To Cell Periphery
Vesicle Uncoating
Regulation Of Protein Localization To Membrane
Protein Transport
Vesicle-mediated Transport
Clathrin-coated Pit
P53 Binding
Clathrin-coated Vesicle
Establishment Of Protein Localization
AP-1 Adaptor Complex
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of JNK Cascade
Negative Regulation Of RNA Metabolic Process
Ubiquitin Protein Ligase Binding
Endolysosome Membrane
Transcytosis
Cytosol
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Serine/threonine Kinase Binding
Clathrin-coated Endocytic Vesicle
Negative Regulation Of Macromolecule Biosynthetic Process
Disordered Domain Specific Binding
Regulation Of JNK Cascade
Regulation Of Proteolysis
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Receptor Internalization
Lysosomal Membrane
Regulation Of Synaptic Vesicle Recycling
Negative Regulation Of Protein Localization To Plasma Membrane
Enzyme Binding
Regulation Of Protein Localization To Nucleus
Clathrin-dependent Endocytosis
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Component Assembly
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Tagcloud (Intersection)
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