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AXIN1 and DAB2
Number of citations of the paper that reports this interaction (PubMedID
12805222
)
52
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro)
AXIN1
DAB2
Description
axin 1
DAB adaptor protein 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Fibrillar Center
Cytoplasm
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Clathrin-coated Vesicle
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Molecular Function
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Protein Binding
Clathrin Adaptor Activity
Cargo Receptor Activity
SMAD Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Endocytosis
Receptor-mediated Endocytosis
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Neuron Projection Development
Protein Transport
Wnt Signaling Pathway
Cell Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Aldosterone Biosynthetic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Leading Edge Cell Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Clathrin Coat Assembly
Response To Steroid Hormone
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Salt
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Aldosterone Secretion
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Gap junction degradation
Formation of annular gap junctions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
1,4-Dithiothreitol
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
33547301
29403010
)
Birth weight (
31043758
)
Chronic kidney disease (
20383146
31152163
)
Creatinine levels (
31015462
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31451708
31152163
30604766
31015462
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
Health literacy (
31250787
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Non-albumin protein levels (
29403010
)
Pancreatic cancer (
22158540
)
Premature menopause in childhood cancer survivors (
29432556
)
Self-reported allergy (
23817569
)
Systemic lupus erythematosus (
19838195
)
Urate levels (
23263486
)
Waist-hip ratio (
28552196
)
Interacting Genes
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
40 interacting genes:
AP2M1
APLP1
APLP2
APP
ATXN1L
AXIN1
CDC16
CDK1
CSK
DAB2IP
DIP2A
DVL1
DVL3
FCHO1
FCHO2
FGR
GRB2
INPP5D
ITGB3
ITGB5
ITSN1
LDLR
LRP1
LRP2
LRP8
MIB1
MYO6
NECAP1
PIN1
PRKCB
PRKCD
PRKCG
SGIP1
SMAD2
SMAD3
SMURF2
SRC
SUMO2
TGFBR1
TGFBR2
Entrez ID
8312
1601
HPRD ID
04819
03139
Ensembl ID
ENSG00000103126
ENSG00000153071
Uniprot IDs
A0A0S2Z4R0
A0A0S2Z4S3
O15169
B2RAW0
P98082
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
2LSW
6O5O
6OVF
Enriched GO Terms of Interacting Partners
?
Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
Clathrin-coated Pit
Endocytosis
Import Into Cell
Plasma Membrane
Cell Surface Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Receptor Complex
Signal Transduction
Regulation Of Endocytosis
Regulation Of Vesicle-mediated Transport
Receptor-mediated Endocytosis
Vesicle-mediated Transport
Regulation Of Cellular Component Organization
Intracellular Signal Transduction
Regulation Of Protein Catabolic Process
Regulation Of Signaling
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Developmental Process
Response To Growth Factor
Regulation Of Cell Communication
Clathrin-dependent Endocytosis
Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Tube Morphogenesis
Positive Regulation Of Protein Catabolic Process
Regulation Of Transport
Low-density Lipoprotein Particle Receptor Activity
Membrane
I-SMAD Binding
Cellular Response To Oxygen-containing Compound
Presynaptic Endocytosis
Regulation Of Cellular Response To Growth Factor Stimulus
Vesicle-mediated Transport In Synapse
Regulation Of Protein Localization
Immune Response-activating Cell Surface Receptor Signaling Pathway
SMAD Binding
Cytosol
Positive Regulation Of Lysosomal Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Neuron Projection Morphogenesis
Enzyme-linked Receptor Protein Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Cell Projection Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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