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AXIN1 and RNF111
Number of citations of the paper that reports this interaction (PMID
16601693
)
42
Data Source:
HPRD
(in vitro, in vivo)
AXIN1
RNF111
Gene Name
axin 1
ring finger protein 111
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Microtubule
Cell Cortex
Postsynaptic Density
Cytoplasmic Membrane-bounded Vesicle
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein Complex
Molecular Function
P53 Binding
Signal Transducer Activity
GTPase Activator Activity
Receptor Binding
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Enzyme Binding
Protein Kinase Binding
Receptor Signaling Complex Scaffold Activity
Ubiquitin Protein Ligase Binding
Protein Complex Scaffold
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
SMAD Binding
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Polymer Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
In Utero Embryonic Development
Optic Placode Formation
Positive Regulation Of Protein Phosphorylation
Nucleocytoplasmic Transport
Apoptotic Process
Activation Of JUN Kinase Activity
Determination Of Left/right Symmetry
Sensory Perception Of Sound
Cell Death
Dorsal/ventral Axis Specification
Positive Regulation Of Peptidyl-threonine Phosphorylation
Forebrain Anterior/posterior Pattern Specification
Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Olfactory Placode Formation
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Catenin Import Into Nucleus
Post-anal Tail Morphogenesis
Termination Of G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of GTPase Activity
Cellular Protein Complex Assembly
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Embryonic Eye Morphogenesis
Axial Mesoderm Formation
Negative Regulation Of Protein Metabolic Process
Protein Homooligomerization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Muscle Cell Development
Canonical Wnt Signaling Pathway
Embryonic Skeletal Joint Morphogenesis
Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation
Cellular Response To Organic Cyclic Compound
Genetic Imprinting
Negative Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Gene Expression
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
degradation of AXIN
Signaling by WNT in cancer
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Class I MHC mediated antigen processing & presentation
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Bone mineral density (
22504420
)
Asperger disorder (
21182207
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
43 interactors:
AMER1
ANP32A
APC
BTRC
CARM1
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
GAK
GNAS
GSK3B
JUP
LMO2
LRP5
LRP6
MAP3K4
MYC
MYOT
NCK2
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
RNF111
RUNX2
SENP2
SH3GL1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
UTP14A
39 interactors:
ACTN3
ANAPC11
AXIN1
CREB1
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP5-9
LCE4A
LRSAM1
MARCH7
MVP
PHF7
PML
SMAD3
SMAD6
SMAD7
SMURF2
SUMO2
TRAF5
TRIM21
TRIM8
TSG101
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2Q2
UBE2V1
UBE2W
Entrez ID
8312
54778
HPRD ID
04819
09318
Ensembl ID
ENSG00000103126
ENSG00000157450
Uniprot IDs
O15169
Q6ZNA4
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
2KIZ
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Signal Transduction
Wnt Signaling Pathway
Regulation Of Signaling
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cellular Response To Stimulus
Signaling
Cell Communication
Negative Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Signaling
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cell Differentiation
Cellular Response To Growth Factor Stimulus
Regulation Of Gene Expression
Canonical Wnt Signaling Pathway
Response To Growth Factor
Positive Regulation Of Protein Metabolic Process
Cellular Response To Organic Substance
Regulation Of Phosphorus Metabolic Process
Tissue Development
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Regulation Of Cellular Protein Metabolic Process
Response To Organic Substance
Positive Regulation Of Metabolic Process
Organ Morphogenesis
Anatomical Structure Development
System Development
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Organ Morphogenesis
Regulation Of Nitrogen Compound Metabolic Process
Developmental Process
Organ Development
Multicellular Organismal Development
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Protein Phosphorylation
Cellular Response To Transforming Growth Factor Beta Stimulus
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Polyubiquitination
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein K11-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Catabolic Process
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Gene Expression
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Protein Monoubiquitination
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Catabolic Process
Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud
?
aberrations
applying
arid2
cdk15
cps1
creating
deleterious
disruptions
drive
driver
fn1
fusions
genomes
hccs
hnf4a
integrations
intronic
mll4
recurrently
rps6ka3
seq
silent
splice
tert
thrap3
transcriptomes
transcriptomic
tsc1
wgs
Tagcloud (Difference)
?
aberrations
applying
arid2
cdk15
cps1
creating
deleterious
disruptions
drive
driver
fn1
fusions
genomes
hccs
hnf4a
integrations
intronic
mll4
recurrently
rps6ka3
seq
silent
splice
tert
thrap3
transcriptomes
transcriptomic
tsc1
wgs
Tagcloud (Intersection)
?