MAP1LC3A and EPHA7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAP1LC3A	EPHA7
Description		microtubule associated protein 1 light chain 3 alpha	EPH receptor A7
Image
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse	Plasma Membrane Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Growth Factor Binding Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation	Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Brain Development Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Negative Chemotaxis Neuron Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Regulation Of Postsynapse Organization
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Adult body size ( 32376654) Adventurousness ( 30643258) Anthropometric traits (multi-trait analysis) ( 30166351) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Initial pursuit acceleration ( 29064472) Laryngeal squamous cell carcinoma ( 25194280) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to hepatitis C treatment ( 22095909) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304	12 interacting genes: AFDN DUSP18 DUSP26 EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MTMR14 STYX ZNF267
Entrez ID		84557	2045
HPRD ID		03144	03721
Ensembl ID		ENSG00000101460	ENSG00000135333
Uniprot IDs		Q9H492	A0A7P0T9G1 A0A7P0T9L5 A0A7P0T9V9 A0A7P0TA58 Q15375
PDB IDs		3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T	2REI 3DKO 3H8M 3NRU 7EEC 7EED 7EEF
Enriched GO Terms of Interacting Partners?		Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Guidance Axon Guidance Protein Serine/threonine Phosphatase Activity Transmembrane-ephrin Receptor Activity Protein Tyrosine/serine/threonine Phosphatase Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Pseudophosphatase Activity Phosphatase Activity Protein Dephosphorylation Regulation Of Cell Adhesion Notochord Formation F-box Domain Binding Protein Tyrosine Phosphatase Activity Plasma Membrane Bounded Cell Projection Organization Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Oxygen-glucose Deprivation
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