MAP1LC3A and RIC1

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		MAP1LC3A	RIC1
Description		microtubule associated protein 1 light chain 3 alpha	RIC1 partner of RAB6A GEF complex
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse	Golgi Membrane Cytoplasm Cytosol Membrane Trans-Golgi Network Membrane Protein-containing Complex Ric1-Rgp1 Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation	Regulation Of Extracellular Matrix Constituent Secretion Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Negative Regulation Of Protein Catabolic Process Positive Regulation Of GTPase Activity Cranial Skeletal System Development
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Serum alkaline phosphatase levels ( 33339817 33547301)
Interacting Genes		100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304	2 interacting genes: MAP1LC3A MAP1LC3B
Entrez ID		84557	57589
HPRD ID		03144	13858
Ensembl ID		ENSG00000101460	ENSG00000107036
Uniprot IDs		Q9H492	Q4ADV7
PDB IDs		3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T
Enriched GO Terms of Interacting Partners?		Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Maturation Organelle Membrane Autophagosome Membrane Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Microtubule Binding Cellular Response To Nutrient Levels Endomembrane System Autophagy Ubiquitin Protein Ligase Binding Microtubule Cellular Response To Oxygen-glucose Deprivation Response To Nutrient Levels Response To Iron(II) Ion Ceramide Binding Response To Oxygen-glucose Deprivation Autolysosome Organelle Assembly Response To Lead Ion Cytoplasmic Vesicle Cellular Response To Copper Ion SMAD Protein Signal Transduction P38MAPK Cascade Response To Iron Ion Response To Copper Ion Protein-containing Complex Organization Cytoskeleton Cellular Response To Amino Acid Starvation JNK Cascade Response To Amino Acid Starvation Cellular Response To Hydrogen Peroxide Cellular Response To Stress Response To Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Axoneme Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Late Endosome
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