MAP1LC3A and ANK3

Number of citations of the paper that reports this interaction (PubMedID 29867141)
0

Data Source:
BioGRID (pull down)

		MAP1LC3A	ANK3
Description		microtubule associated protein 1 light chain 3 alpha	ankyrin 3
Image
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse	Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Axon Dendrite Neuromuscular Junction Node Of Ranvier Sarcolemma Cell Projection Neuron Projection Costamere Axon Initial Segment Organelle Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Anchor Activity Sodium Channel Regulator Activity Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding Cadherin Binding Channel Activator Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Signal Transduction Axonogenesis Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Golgi Vesicle Transport Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Protein Localization To Axon Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Bipolar disorder ( 18711365 33263727 31043756 34002096 28072414 24618891 22182935 21926972 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Frailty index ( 34431594) Heel bone mineral density ( 30598549) Height ( 31562340) Metabolite levels ( 23823483) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Psychotic experience ( 31553412) Refractive error ( 32231278) Schizophrenia ( 20185149) Third ventricle volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304	22 interacting genes: FADD FAS GABARAP HOOK1 KCNC1 MAP1LC3A MAP1LC3C MAPK6 NAB2 NEDD4 PIK3R1 PLEC RIPK4 RNF10 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4 SRPK2 YAP1
Entrez ID		84557	288
HPRD ID		03144	02715
Ensembl ID		ENSG00000101460	ENSG00000151150
Uniprot IDs		Q9H492	Q12955 Q8NAK2
PDB IDs		3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T	4O6X
Enriched GO Terms of Interacting Partners?		Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity	Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Phosphatidylethanolamine Binding Node Of Ranvier Paraxial Mesoderm Morphogenesis SMAD Protein Signal Transduction Autophagosome Signal Transduction Response To Nutrient Levels Protein-containing Complex Organization Mesoderm Morphogenesis CD95 Death-inducing Signaling Complex Pericardium Development Death-inducing Signaling Complex SMAD Protein Complex Trophoblast Cell Migration Sodium Channel Complex Phospholipid Binding Cellular Response To Nutrient Levels Heteromeric SMAD Protein Complex Ameboidal-type Cell Migration Sodium Channel Inhibitor Activity Autophagosome Maturation Necroptotic Signaling Pathway Phosphatase Binding Autophagosome Membrane Negative Regulation Of Programmed Cell Death Cytosol Embryonic Foregut Morphogenesis Mitophagy Mesenchyme Development Regulation Of Programmed Cell Death Autolysosome Nodal Signaling Pathway Co-SMAD Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleocytoplasmic Transport Voltage-gated Sodium Channel Complex Primary MiRNA Processing Regulation Of Sodium Ion Transport Vacuole Organization Cellular Response To Starvation Motor Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Binding Wound Healing Sodium Ion Transport
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