MAP1LC3A and SEC62

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		MAP1LC3A	SEC62
Description		microtubule associated protein 1 light chain 3 alpha	SEC62 preprotein translocation factor
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation	Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Transport Post-translational Protein Targeting To Membrane, Translocation
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Cadmium levels ( 26025379)
Interacting Genes		100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304	8 interacting genes: CIC CTNNB1 GABARAP GABARAPL1 MAP1LC3A OGT SEC63 ZNF24
Entrez ID		84557	7095
HPRD ID		03144	03706
Ensembl ID		ENSG00000101460	ENSG00000008952
Uniprot IDs		Q9H492	Q99442
PDB IDs		3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T	7BRT
Enriched GO Terms of Interacting Partners?		Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity	Mitophagy Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Macroautophagy Autophagosome Maturation Autophagosome Membrane Cellular Response To Nutrient Levels Ubiquitin Protein Ligase Binding Autophagy Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding GABA Receptor Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein-containing Complex Disassembly Response To Nutrient Levels Vacuole Organization Regulation Of Protein Localization To Synapse Cellular Response To Starvation Regulation Of Protein Ubiquitination Regulation Of Receptor Localization To Synapse Regulation Of Rac Protein Signal Transduction Response To Starvation Regulation Of Post-translational Protein Modification Beta-tubulin Binding Organelle Assembly Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Sec62/Sec63 Complex Microtubule Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Negative Regulation Of Post-translational Protein Modification Catabolic Process Oviduct Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Fungiform Papilla Formation
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