LRP1 and NOS1AP

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		LRP1	NOS1AP
Gene Name		low density lipoprotein receptor-related protein 1	nitric oxide synthase 1 (neuronal) adaptor protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Nucleus Mitochondrion Cytosol Caveola Z Disc T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Nitric-oxide Synthase Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)	Electrocardiographic traits ( 20062061 20062063) Obesity-related traits ( 23251661) QT interval ( 23166209 20031603 16648850 22726844 19305408 19305409 19587794) Word reading ( 23738518)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	11 interactors: APP FAM133A LRP1 LRP2 LRP8 NOS1 RASD1 SYN1 SYN2 SYN3 TRAF4
Entrez ID		4035	9722
HPRD ID		00138	12023
Ensembl ID		ENSG00000123384	ENSG00000198929
Uniprot IDs		Q07954 Q59FG2	O75052
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Regulation Of Neurotransmitter Levels Signaling Cell Communication Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Synaptic Transmission Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Response To Light Stimulus Neurotransmitter Secretion Detection Of Light Stimulus Isoprenoid Metabolic Process Nitric Oxide Mediated Signal Transduction Response To Radiation Neurotransmitter Transport Secretion By Cell Response To Abiotic Stimulus Detection Of Abiotic Stimulus Regulation Of Signaling Secretion Endocytosis Steroid Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Receptor-mediated Endocytosis Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Ammon Gyrus Development Beta-amyloid Clearance Regulation Of Cellular Amino Acid Metabolic Process Blood Coagulation Hemostasis Forebrain Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Ketone Metabolic Process Cholesterol Metabolic Process Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Sterol Metabolic Process Lipid Metabolic Process Detection Of Stimulus Regulation Of Body Fluid Levels Second-messenger-mediated Signaling
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn impa2 metabotropic ncam1 nd4 ndufv2 nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn impa2 metabotropic ncam1 nd4 ndufv2 nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah
Tagcloud (Intersection) ?