LRP1 and CD82

Number of citations of the paper that reports this interaction (PMID 9804823)
16

Data Source:
HPRD (in vivo, in vitro)

		LRP1	CD82
Gene Name		low density lipoprotein receptor-related protein 1	CD82 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Protein Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)	Hemostatic factors and hematological phenotypes ( 22443383)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	21 interactors: CANX CD19 CD4 CD63 EGFR ERBB2 ERBB3 HBEGF HLA-DMA HLA-DMB HLA-DRA IGSF8 ITGA3 ITGA4 ITGA6 ITGB1 ITGB2 LRP1 NUP88 PTGFRN VANGL1
Entrez ID		4035	3732
HPRD ID		00138	09004
Ensembl ID		ENSG00000123384
Uniprot IDs		Q07954 Q59FG2	P27701
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Regulation Of Immune Response Immune System Process Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Cell-matrix Adhesion Immune Response-regulating Signaling Pathway Response To Wounding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Cell-substrate Adhesion Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Integrin-mediated Signaling Pathway Immune Response Phosphatidylinositol-mediated Signaling Movement Of Cell Or Subcellular Component Single Organismal Cell-cell Adhesion Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Cell Adhesion ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Developmental Process Cell Motility Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell-cell Adhesion Response To Fibroblast Growth Factor Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neurotrophin TRK Receptor Signaling Pathway Heterotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cellular Extravasation Cell Activation Leukocyte Migration Neurotrophin Signaling Pathway Blood Coagulation Fc-epsilon Receptor Signaling Pathway Hemostasis Protein Localization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Multicellular Organismal Development
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	additionally connexin32 contributes cx32 downregulated downregulation frequently hcc hepatocellular imply inhibiting invasion investigations kai1 metastasis negatively nude poor progresses promising rapidly recurrence repressed restoration suppress suppressor thereby upregulating vascular
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	additionally connexin32 contributes cx32 downregulated downregulation frequently hcc hepatocellular imply inhibiting invasion investigations kai1 metastasis negatively nude poor progresses promising rapidly recurrence repressed restoration suppress suppressor thereby upregulating vascular
Tagcloud (Intersection) ?