NOS1AP and SYN1

Number of citations of the paper that reports this interaction (PubMedID 11867766)
44

Data Source:
HPRD (in vivo)

		NOS1AP	SYN1
Description		nitric oxide synthase 1 adaptor protein	synapsin I
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Mitochondrion Cytosol Caveola Z Disc Filopodium T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Glutamatergic Synapse	Synaptonemal Complex Golgi Apparatus Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Cell Body Synapse Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Presynapse Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Nitric-oxide Synthase Regulator Activity Signaling Adaptor Activity Nitric-oxide Synthase Binding	Actin Binding Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Regulation Of Heart Rate By Chemical Signal Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Body mass index (change over time) ( 25133637) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062061 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Long QT syndrome ( 32429735) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) QT interval ( 19305408 19305409 19587794 30679814 16648850 29874175 29213071 20031603 22726844 23166209 24952745) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Word reading ( 23738518)
Interacting Genes		18 interacting genes: AKNAD1 APP CKM FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		9722	6853
HPRD ID		12023	02433
Ensembl ID		ENSG00000198929	ENSG00000008056
Uniprot IDs		O75052	P17600
PDB IDs
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Synaptic Vesicle Cycle Synaptic Vesicle Clustering Low-density Lipoprotein Particle Receptor Activity Clathrin-coated Pit Synaptic Signaling Cargo Receptor Activity Schaffer Collateral - CA1 Synapse Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Postsynaptic Density Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Neurotransmitter Secretion Chemical Synaptic Transmission Response To Growth Factor Trans-synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Protein Catabolic Process In The Vacuole Cell-cell Signaling Regulation Of Protein Catabolic Process Signaling Response To Amyloid-beta Cell Communication Receptor Complex High-density Lipoprotein Particle Binding Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Reelin-mediated Signaling Pathway Diterpenoid Metabolic Process Cell Body Regulation Of Dendritic Spine Maintenance Calcium-dependent Protein Binding Dendrite Extrinsic Component Of Synaptic Vesicle Membrane Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Synapse Organization Terpenoid Metabolic Process Vesicle-mediated Transport In Synapse Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Neuron Projection Morphogenesis Astrocyte Activation Layer Formation In Cerebral Cortex Isoprenoid Metabolic Process Neurotransmitter Transport	Cytosol Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Biological Quality Regulation Of Organelle Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Postsynaptic Density Regulation Of Cellular Localization Presynaptic Endocytosis Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Protein-containing Complex Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Neurotrophin TRKA Receptor Binding Protein Serine Kinase Activity Protein Kinase Activity Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Component Size Cellular Response To Nutrient Levels Protein Serine/threonine Kinase Activity Glutamatergic Synapse Actin Filament-based Process Cytoskeleton Organization Regulation Of Developmental Process Regulation Of Neuron Projection Development Kinase Activity Regulation Of Innate Immune Response Regulation Of Transport Cell Junction Organization Response To Growth Factor Regulation Of Heart Contraction Positive Regulation Of Protein-containing Complex Assembly
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